Development of a Zein-Based System for Colon Specific Delivery

Nguyen, Minh Ngoc-Uyen; Van, Toi Vo; Tran, Phuong Ha-Lien; Tran, Thao

doi:10.1007/978-981-10-4361-1_85

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…Its biodegradability, biocompatibility, availability, low cost as well as safety (classified as GRAS by the FDA) made it a suitable candidate for drug delivery applications [77]. Among those applications, zein was utilized for the fabrication of scaffolds for tissue engineering [78][79][80][81][82], vaccine delivery [83], DNA transfection [84], oral delivery of peptides and proteins [85], and colon-specific drug delivery [86]. The rising potential of the specific use of zein in bone tissue engineering refers to its perfect membrane forming ability (osteoconductivity), optimum biodegradability, suitable mechanical properties (toughness, flexibility, and compressibility), resistance to degradation by microbial enzymes, and intrinsic anti-oxidant activity [87,88].…”

Section: Zeinmentioning

confidence: 99%

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

2022

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Tissue engineering has emerged as an interesting field nowadays; it focuses on accelerating the auto-healing mechanism of tissues rather than organ transplantation. It involves implanting an In Vitro cultured initiative tissue or a scaffold loaded with tissue regenerating ingredients at the damaged area. Both techniques are based on the use of biodegradable, biocompatible polymers as scaffolding materials which are either derived from natural (e.g. alginates, celluloses, and zein) or synthetic sources (e.g. PLGA, PCL, and PLA). This review discusses in detail the recent applications of different biomaterials in tissue engineering highlighting the targeted tissues besides the in vitro and in vivo key findings. As well, smart biomaterials (e.g. chitosan) are fascinating candidates in the field as they are capable of elucidating a chemical or physical transformation as response to external stimuli (e.g. temperature, pH, magnetic or electric fields). Recent trends in tissue engineering are summarized in this review highlighting the use of stem cells, 3D printing techniques, and the most recent 4D printing approach which relies on the use of smart biomaterials to produce a dynamic scaffold resembling the natural tissue. Furthermore, the application of advanced tissue engineering techniques provides hope for the researchers to recognize COVID-19/host interaction, also, it presents a promising solution to rejuvenate the destroyed lung tissues. Graphical abstract

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Section: Zeinmentioning

confidence: 99%

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

2022

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“…[13][14][15][16] However, to the best of our knowledge, there has been few reports on the application of Zein-based formulation as a colon-targeted delivery system so far. 17,18 The reason could be derived from at least two aspects: (1) the issues of premature drug release or incomplete disintegration of drug carriers are likely to be encountered, and (2) the designed trigger-release mechanism may fail to work due to possible aggregation of Zein colloidal particles. To address these problems, further suface functionlization of zein-based vehicles is necessary to achieve desirable outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…When orally administered, Zein is relatively resistant to digestive enzymes, which is associated with the fact that Zein particles display a long residence time within the gastrointestinal (GI) tract before being degraded . Because of these advantages, Zein-based particulate systems have received extensive attention as promising delivery vehicles specifically for hydrophobic active molecules. − However, to the best of our knowledge, there have been few reports on the application of Zein-based formulation as a colon-targeted delivery system so far. , The reason could be derived from at least two aspects: (1) the issues of premature drug release or incomplete disintegration of drug carriers are likely to be encountered, and (2) the designed trigger-release mechanism may fail to work due to possible aggregation of Zein colloidal particles. To address these problems, further suface functionlization of zein-based vehicles is necessary to achieve desirable outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…13−16 However, to the best of our knowledge, there have been few reports on the application of Zein-based formulation as a colon-targeted delivery system so far. 17,18 The reason could be derived from at least two aspects: (1) the issues of premature drug release or incomplete disintegration of drug carriers are likely to be encountered, and…”

Section: Introductionmentioning

confidence: 99%

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Self-Assembly of Zein-Based Microcarrier System for Colon-Targeted Oral Drug Delivery

Wang

Zhang

Wang

et al. 2018

Ind. Eng. Chem. Res.

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The advances in pharmaceutical technology allow for the development of various region-selective delivery systems for oral administration to optimize local and systemic therapy. In this paper, micronization associated with a polymorph modification approach was proposed for improving the solubility of hydrophobic drugs for developing a Zein-based colon-targeted delivery system. A microcarrier based on self-assembled structures of Zein was fabricated via a built-in ultrasonic dialysis process, which displayed high payload of a model drug, indomethacin (Indo), with its optimal crystal form. The possible self-assembly mechanism of Zein/Indo forming porous structure in the ultrasonic dialysis process was attributed to the results of intra-and/or inter-molecular interactions between Zein and Indo. The designed microspheres, Zein-Indo@PDA, with a surface coating of polydopamine (PDA) not only rendered them enhanced stability and mechanical resistance, but also hindered the premature drug release at undesired sites. This innovative formulation design may offer better chances of colon-targeted release.

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