Development of a xylose-inducible promoter and riboswitch combination system for manipulating gene expression in
Fusobacterium nucleatum
Bibek G C,
Peng Zhou,
Arindam Naha
et al.
Abstract:Inducible gene expression systems are important for studying bacterial gene function, yet most exhibit leakage. In this study, we engineered a leakage-free hybrid system for precise gene expression controls in
Fusobacterium nucleatum
by integrating the xylose-inducible expression system with the theophylline-responsive riboswitch. This innovative method enables concurrent control of target gene expression at both transcription and translation initiation levels. Using luciferase and the … Show more
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