Development of a Validated Stability-Indicating LC Method for Nitazoxanide in Pharmaceutical Formulations

Stripping voltammetric methods for determination of the antiparasitic drug nitazoxanide in bulk form, pharmaceutical formulation and human serum

“…The satisfactory results obtained by means of the described stripping voltammetric methods using both the calibration curve and standard addition methods (Table 3) were statistically compared with those obtained by a reported RP-LC method. 8 The calculated F-values did not exceed the theoretical ones (Table 3), which means that there is no significant difference between the described stripping voltammetric and the reported RP-LC 8 methods with respect to reproducibility. 32 Also, no significant differences were noticed between the described and reported methods regarding the accuracy and precision as revealed by t-test.…”

“…Chromatographic [4][5][6][7][8][9][10] and spectrophotometric [11][12][13] analytical methods have been reported for determination of nitazoxanide in the bulk form as well as in pharmaceutical formulations. The reported chromatographic methods [4][5][6][7][8][9][10] necessitate sample pretreatment and time-consuming extraction steps prior to analysis of the drug. Moreover, these methods require expensive equipment and considerable skills are necessary to operate them successfully.…”

Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with HPLC

“…In our previous research paper, 14 we reported a validated LC method for the determination of NTZ in pharmaceutical formulations, but the development of a more convenient, simple, less time-consuming and economical direct UV-spectrophotometric method for routine analysis of NTZ in pharmaceutical formulations is highly desirable.…”

“…Data were acquired and processed by Shimadzu Class-VP ® V 6.14 software program (Shimadzu, Kyoto, Japan). The LC method previously developed and validated by our research group was used for comparison with the proposed spectrophotometric method 14 . The column utilized was a Phenomenex ® (Torrance, CA, USA) Synergi Fusion C 18 column (250 mm x 4.6 mm, i.d., 4 µm particle size) coupled to a C 18 guard column (4.0 mm x 3.0 mm, i.d., 4 µm).…”

“…[7][8][9] Recently, methods for the estimation of NTZ in bulk and pharmaceuticals formulations were develope in visible spectrophotometry, 10 high-performance thin-layer chromatographiy (HPTLC) and LC. [11][12][13][14] Several of these methods require the use of hazardous and expensive chemicals, which make the process not only a challenge for the environment but also complex and time consuming. Chromatographic techniques are time consuming, costly and require expertise.…”