Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application

Ou, Fengting; Zhou, Ying; Lei, Jinxiu; Zeng, Su; Wu, Fan; Zhang, Ning; Yu, Lushan

doi:10.1016/j.jpha.2019.09.002

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…A Chiralpak IG column was used to analyze stereoisomeric impurities of brivaracetam [ 64 ]. Separation and quantification of ilaprazole enantiomers in rat plasma was performed on a Chiralpak AS-RH (coated amylose tris(( S )-α-methylbenzylcarbamate)) column allowing MS detection with proper mobile phase compositions [ 65 ]. A Chiralpak AS-3R column (particle size 3 µm) was used for separation of (±)-cetirizine and enantiopurity assessment of R -levocetirizine [ 66 ].…”

Section: Polysaccharide-based Stationary Phasesmentioning

confidence: 99%

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

Grybinik

Bosáková

2021

Monatsh Chem

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Graphic abstract This review provides a brief survey of chiral separation of pharmaceutically active substances published over the last 3 years (2018–2020). Chiral separation of drugs is an important area of research. The control of enantiomeric purity and determination of individual enantiomeric drug molecules is a necessity especially for clinical, analytical, and regulatory purposes. Among chromatographic resolution methods, high-performance liquid chromatography based on chiral stationary phases remains the most popular and effective method used for chiral separation of various drugs. In this review, attention is paid to several classes of chiral stationary phases that have been the most frequently used for drug enantioseparation during this period.

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Section: Polysaccharide-based Stationary Phasesmentioning

confidence: 99%

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

Grybinik

Bosáková

2021

Monatsh Chem

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“…The validated method was applied to study the stereoselective pharmacokinetics of ILA in rats after the intragastric administration of the racemic form of the drug. The results showed significantly higher bioavailability of R ‐ILA in rats than that of S ‐ILA [92].…”

Section: Hplc Methodsmentioning

confidence: 99%

Chiral separation in the class of proton pump inhibitors by chromatographic and electromigration techniques: An overview

et al. 2021

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Chiral separation in the class of proton pump inhibitors by chromatographic and electromigration techniques: An overviewProton pump inhibitors (PPIs) are benzimidazole-derivative chiral sulfoxides, frequently used in the treatment of gastric hyperacidity-related disorders. Due to their stereoselective metabolism, the eutomeric forms of PPIs can present a more advantageous pharmacokinetic profile by comparison with the distomers or racemates. Moreover, two representatives of the class are used in therapy both as racemates and as pure enantiomers (esomeprazole, dexlansoprazole). A relatively large number of enantioseparation methods employed for the stereoselective determination of PPIs from pharmaceutical, biological, and environmental matrices were published in the past three decades. The purpose of the current overview is to provide a systematic survey of the available chiral separation methods published since the introduction of PPIs in the therapy up to the present. Analytical and bioanalytical methods using different chromatographic and electromigration techniques reported for the enantioseparation of omeprazole, lansoprazole, pantoprazole, rabeprazole, ilaprazole, and tenatoprazole are included. The analytical conditions of the presented methods are summarized in three comprehensive tables, while a critical discussion of the applied techniques, possible mechanism of enantiorecognition, and future perspectives on the topic are also presented.

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“…[36][37][38] A study revealed that the S-isomer/Risomer ratio of propranolol and its sulfate and glucuronide conjugates were varied in human serum and urine. 39,40 Methadone, marketed as a racemic mixture 15 Hamman et al, 16 and Tan et al 17 Fexofenadine Antihistamines S < R --S > R Miura et al 18 Venlafaxine Antidepressant -Vd = S < R S < R S < R Eap et al 19 and Godoy et al 20 Tramadol Opioids 21 and Fliegert et al 22 Ketamine General anesthetic and NMDA receptor antagonist 23 and Larenza et al 24 Dioxopromethazine 25 Econazole Antifungal Same --E1 > E2 Zhang et al 26 Ilaprazole Proton pump inhibitor S < R S < R -S < R Ou et al 27 Ondansetron Competitive serotonin type 3 receptor antagonist.…”

Section: Pharmacokinetics Of Chiral Drugsmentioning

confidence: 99%

Advances and challenges in the pharmacokinetics and bioanalysis of chiral drugs

2022

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Enantioselective analytical approaches are essential for monitoring pharmacokinetics and acquiring accurate data to better understand the role of stereochemistry in pharmacokinetics. Enantioselectivity significantly impacts the pharmacokinetics of chiral drugs, especially in metabolic profile, leading to toxicity of enantiomer. Consequently, there is a need to study the pharmacokinetics of enantiomerically pure drugs and racemates as they differ in affinity with enzymes and proteins. Combining the best enantioseparation conditions with the specified biological matrix and the intended purpose of the analysis is a challenging task. This review discusses the importance of chirality in stereoselective pharmacokinetics with more relevant examples, various enantioselective analytical techniques, and stationary phases employed. Challenges such as lack of universal chiral columns, biological inversion of the isomers, and others have been discussed. Further presented the recent advances in the screening of chiral drugs and innovative improvements in the analytical approaches for chiral molecule analysis such as supercritical fluid chromatography, simulated moving bed chromatography, and other techniques are discussed.

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Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application

Cited by 10 publications

References 21 publications

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

Chiral separation in the class of proton pump inhibitors by chromatographic and electromigration techniques: An overview

Advances and challenges in the pharmacokinetics and bioanalysis of chiral drugs

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