Development of a ubiquitously transferrable silver‐nanoparticle‐loaded polymer nanosheet as an antimicrobial coating

Ito, Keisuke; Saito, Akihiro; Fujie, Toshinori; Miyazaki, Hiromi; Kinoshita, Manabu; Saitoh, Daizoh; Ohtsubo, Shinya; Takeoka, Shinji

doi:10.1002/jbm.b.33429

Cited by 17 publications

(7 citation statements)

References 32 publications

(39 reference statements)

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“…Ito et al have prepared a highly flexible, strong adhesion, and transferrable AgNPs-loaded polymer nanosheet using the layer-by-layer assembly technique [ 43 ]. Here, poly (ethyleneimine) (PEI) is a cationic polymer and could adhere on SS/PVA film surface via the electric interaction between PEI and the negatively charged groups exposed on the surface of SS/PVA film.…”

Section: Resultsmentioning

confidence: 99%

In Situ Synthesis of Silver Nanoparticles on the Polyelectrolyte-Coated Sericin/PVA Film for Enhanced Antibacterial Application

Cai

Tao

et al. 2017

Materials

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To develop silk sericin (SS) as a potential antibacterial biomaterial, a novel composite of polyelectrolyte multilayers (PEMs) coated sericin/poly(vinyl alcohol) (SS/PVA) film modified with silver nanoparticles (AgNPs) has been developed using a layer-by-layer assembly technique and ultraviolet-assisted AgNPs synthesis method. Ag ions were enriched by PEMs via the electrostatic attraction between Ag ions and PEMs, and then reduced to AgNPs in situ with the assistance of ultraviolet irradiation. PEMs facilitated the high-density growth of AgNPs and protected the synthesized AgNPs due to the formation of a 3D matrix, and thus endowed SS/PVA film with highly effective and durable antibacterial activity. Scanning electron microscopy, energy dispersive spectroscopy, X-ray diffractometry, Fourier transfer infrared spectroscopy, water contact angle, mechanical property and thermogravimetric analysis were applied to characterize SS/PVA, PEMs-SS/PVA and AgNPs-PEMs-SS/PVA films, respectively. AgNPs-PEMs-SS/PVA film has exhibited good mechanical performance, hydrophilicity, water absorption capability as well as excellent and durable antibacterial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and good stability and degradability. This study has developed a simple method to design and prepare AgNPs-PEMs-SS/PVA film for potential antibacterial application.

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Section: Resultsmentioning

confidence: 99%

In Situ Synthesis of Silver Nanoparticles on the Polyelectrolyte-Coated Sericin/PVA Film for Enhanced Antibacterial Application

Cai

Tao

et al. 2017

Materials

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“…The results suggest that ASC spheroids carried by the nanosheet can be used for treatment of skin/subcutaneous tissue resulting from various diseases such as critical limb ischemia. Additionally, our previous studies showed that medicinal ingredients (e.g., silver nanoparticles 41 and tetracycline 42 ) can be easily carried inside a nanosheet. By using this scheme, further enhancement of wound healing is expected.…”

Section: Discussionmentioning

confidence: 99%

Enhanced cellular engraftment of adipose-derived mesenchymal stem cell spheroids by using nanosheets as scaffolds

Nagano

Suematsu

Takuma

et al. 2021

Sci Rep

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The short survival time of transplanted adipose-derived mesenchymal stem cells (ASCs) is a problem for skin wound healing. Transplantation after the formation of cellular spheroids has been investigated as a promising method for prolonging cellular survival. However, there have been technical restrictions for transplantation of spheroids in clinical practice. Here, we show an effective method for transplantation of ASC spheroids onto skin wounds in order to efficiently cure refractory ulcers. To assist anchoring of spheroids onto skin wounds, we used a 120-nm-thick free-standing film (nanosheet) that has a highly adhesive property. Bioluminescence imaging showed that ASC spheroids carried by the nanosheet survived for 14 days, which is about two-times longer than that previously reported. Wounds treated with a nanosheet carrying ASC spheroids were 4-times smaller than untreated wounds on day 14. This method for transplantation of spheroids could be applied to cell therapy for various refractory skin wounds.

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“…The authors also fabricated an antimicrobial NS by embedding silver nanoparticles. 7 However, the NS could not be peeled off and then repasted after adhesion to the organ surface which was a problem when the NS had been initially pasted at a slightly different location than intended. To paste such NSs in precise positions, Taccola and colleagues 8,9 developed the NSs with embedded magnetic nanoparticles and evaluated their morphology and magnetic properties.…”

Section: Introductionmentioning

confidence: 99%

Self-standing magnetic composite nanosheets prepared in the presence of an external magnetic field: Characterization and potential for medical applications

Saeedi

Takahashi

Ehara

et al. 2020

Journal of Chemical Research

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The aim of this study is to develop self-standing, ultrathin film, nanosheets with high magnetic response for use in a medical device that can be migrated to a target location in the body by using an external magnetic field. First, iron oxide nanoparticles are synthesized by either the sol-gel method or thermal decomposition. The resulting magnetic properties of the nanoparticles show that the thermal decomposition method provides a greater saturation magnetization value than the sol-gel method. Next, the nanoparticles obtained by the thermal decomposition method are embedded into nanosheets of poly(L-lactide) at varying concentrations. Embedding of the nanoparticles in the composite nanosheets is achieved by the application of an external magnetic field. The composite nanosheets are then characterized. The thickness of the nanosheet increases, and the nanoparticles are well dispersed, with an increase in poly (L-lactide) concentration. The NP-embedded nanosheets are imaged by transmission electron microscopy, which reveals thin, long aggregates aligned in collinear line features. X-ray diffraction results indicate that the magnetic hard axis of the nanoparticles in the nanosheets is aligned in parallel to the plane of the nanosheet by magnetic field application during nanosheet preparation. In addition, the nanosheets at high poly (L-lactide) concentrations that had been subjected to a magnetic field during preparation show a slightly greater magnetic response compared with both nanosheets without magnetic field exposure and nanosheets prepared at low poly (L-lactide) concentrations.

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Development of a ubiquitously transferrable silver‐nanoparticle‐loaded polymer nanosheet as an antimicrobial coating

Cited by 17 publications

References 32 publications

In Situ Synthesis of Silver Nanoparticles on the Polyelectrolyte-Coated Sericin/PVA Film for Enhanced Antibacterial Application

In Situ Synthesis of Silver Nanoparticles on the Polyelectrolyte-Coated Sericin/PVA Film for Enhanced Antibacterial Application

Enhanced cellular engraftment of adipose-derived mesenchymal stem cell spheroids by using nanosheets as scaffolds

Self-standing magnetic composite nanosheets prepared in the presence of an external magnetic field: Characterization and potential for medical applications

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