Development of a U-bent plastic optical fiber biosensor with plasmonic labels for the detection of chikungunya non-structural protein 3

George, Ankitha; Amrutha, M. S.; Srivastava, Priyanshu; Sunil, Sujatha; Sai, V. V. R.; Ramanathan, Surash

doi:10.1039/d0an01603a

Cited by 27 publications

(15 citation statements)

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“…Lastly, the biofunctionalization procedure ends with a passivation step. The most common passivating agents are bovine serum albumin (BSA) [13,31,47,54,[95][96][97][98] and poly(ethylene glycol) (PEG) [99]. These reagents are commonly implemented to reduce the non-specific interactions between the analyte and surface, and also between interferents present in more complex matrixes.…”

Section: Biofunctionalization Strategies For Optical Fiber Immunosensorsmentioning

confidence: 99%

“…Afterwards, the fiber is incubated in HMDA in order to form amine grou the hydrolyzed surface [38,54,99], becoming more hydrophilic. The amine-terminated can be then functionalized with the antibody by direct covalent linkage to the surface GA [99] or using the intermediary Protein A [54], as depicted in Figure 9. Considering the physical adsorption strategy via electrostatic immobilization, as aforementioned, the antibodies possess a negative surface charge at physiological pH conditions, thus the fiber must have a positive surface charge.…”

Section: Plastic Optical Fibermentioning

confidence: 99%

“…First, the sensors are treated with sulfuric acid (H 2 SO 4 ) to reduce methyl ester (-COOCH 3 ) groups through acid hydrolysis, producing carboxylic groups on the POF surface. Afterwards, the fiber is incubated in HMDA in order to form amine groups on the hydrolyzed surface [ 38 , 54 , 99 ], becoming more hydrophilic. The amine-terminated fibers can be then functionalized with the antibody by direct covalent linkage to the surface using GA [ 99 ] or using the intermediary Protein A [ 54 ], as depicted in Figure 9 .…”

Section: Biofunctionalization Strategies For Optical Fiber Immunosensorsmentioning

confidence: 99%

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Immunosensing Based on Optical Fiber Technology: Recent Advances

et al. 2021

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The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented.

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Section: Biofunctionalization Strategies For Optical Fiber Immunosensorsmentioning

confidence: 99%

Section: Plastic Optical Fibermentioning

confidence: 99%

Section: Biofunctionalization Strategies For Optical Fiber Immunosensorsmentioning

confidence: 99%

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Immunosensing Based on Optical Fiber Technology: Recent Advances

et al. 2021

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“…In addition, commercial immunochromatography antigen detection kits are gaining popularity in the recent past owing to their high sensitivity and specificity with no cross-reactivity with other arboviruses ( Okabayashi et al, 2015 ; Jain et al, 2018a ). Other diagnostic initiatives are the use of biosensors using different technologies such as electrochemical impedance spectrometry and optical fibers that have shown promise in CHIKV diagnosis ( George et al, 2019 , 2021 ).…”

Section: Laboratory Diagnosismentioning

confidence: 99%

Current Status of Chikungunya in India

Sunil¹

2021

Front. Microbiol.

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Chikungunya fever (CHIKF) is an arbovirus disease caused by chikungunya virus (CHIKV), an alphavirus of Togaviridae family. Transmission follows a human-mosquito-human cycle starting with a mosquito bite. Subsequently, symptoms develop after 2–6 days of incubation, including high fever and severe arthralgia. The disease is self-limiting and usually resolve within 2 weeks. However, chronic disease can last up to several years with persistent polyarthralgia. Overlapping symptoms and common vector with dengue and malaria present many challenges for diagnosis and treatment of this disease. CHIKF was reported in India in 1963 for the first time. After a period of quiescence lasting up to 32 years, CHIKV re-emerged in India in 2005. Currently, every part of the country has become endemic for the disease with outbreaks resulting in huge economic and productivity losses. Several mutations have been identified in circulating strains of the virus resulting in better adaptations or increased fitness in the vector(s), effective transmission, and disease severity. CHIKV evolution has been a significant driver of epidemics in India, hence, the need to focus on proper surveillance, and implementation of prevention and control measure in the country. Presently, there are no licensed vaccines or antivirals available; however, India has initiated several efforts in this direction including traditional medicines. In this review, we present the current status of CHIKF in India.

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“…Optical fiber is immensely applied as chemical/biosensors [1][2][3][4][5][6]. Its ease of fabrication and implementation, lightweight, high sensitivity, low cost, and immunity to electromagnetic interference are the main advantages of optical fiber as a sensor in comparison to conventional sensors [7].…”

Section: Introductionmentioning

confidence: 99%

U-bent Plastic Optical Fiber for Lard Adulteration Sensor in Edible Oil

Puspita¹,

Kurniawan

Hatta

et al. 2021

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A plastic optical fiber with the structure of U-bent was utilized as a sensor to detect lard adulterants in olive oil. The macro bending was formed on the plastic optical fiber with a bending radius of 10 mm, 12.5 mm, and 15 mm. The output spectra and intensity were measured to detect the existence of lard substance in olive oil. The U-bent plastic optical fiber sensor with a bending radius of 12.5 mm has the optimum performance to detect the lard adulterant substance in olive oil. It has a sensitivity of 4.6 a.u/% with 855 nm LED source and 10.07 a.u/% with 940 nm LED source in intensity-based measurement and 0.50 nm/% in spectrum-based measurement. The proposed sensor is the potential to give rapid detection on lard adulterant in edible oil.

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Development of a U-bent plastic optical fiber biosensor with plasmonic labels for the detection of chikungunya non-structural protein 3

Abstract: This study presents a novel plasmonic fiber optic sandwich immunobiosensor for the detection of chikungunya, an infectious mosquito-borne disease with chronic musculoskeletal pain and acute febrile illness, by exploiting non-structural...

Cited by 27 publications

References 47 publications

Immunosensing Based on Optical Fiber Technology: Recent Advances

Immunosensing Based on Optical Fiber Technology: Recent Advances

Current Status of Chikungunya in India

U-bent Plastic Optical Fiber for Lard Adulteration Sensor in Edible Oil

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