Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation

Galvão, Viviane; Miranda, José García Vivas; Ribeiro-dos-Santos, Ricardo

doi:10.1093/bioinformatics/btn362

Cited by 17 publications

(11 citation statements)

References 23 publications

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“…For instance, cardiac transplant is a procedure that has been applied and has demonstrated clinical benefit in some patients with terminal heart failure [78]. Stem cell transplant is a new therapy applied to produce cardiac regeneration through distinction or increase heart myocytes or neovascular proliferation in patients in the final stage of congestive heart failure [79–81], but the results are still insufficient on Chagas disease, and there is no consensus about its efficacy [80]. …”

Section: Discussionmentioning

confidence: 99%

Therapy of Chagas Disease: Implications for Levels of Prevention

Sosa-Estáni

Colantonio

Segura

2012

Journal of Tropical Medicine

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This paper reviews the evidence supporting the use of etiological treatment for Chagas disease that has changed the standard of care for patients withTrypanosoma cruziinfection in the last decades. Implications of this evidence on different levels of prevention as well as gaps in current knowledge are also discussed. In this regard, etiological treatment has shown to be beneficial as an intervention for secondary prevention to successfully cure the infection or to delay, reduce, or prevent the progression to disease, and as primary disease prevention by breaking the chain of transmission. Timely diagnosis during initial stages would allow for the prescription of appropriate therapies mainly in the primary health care system thus improving chances for a better quality of life. Based on current evidence, etiological treatment has to be considered as an essential public health strategy useful to reduce disease burden and to eliminate Chagas disease altogether.

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Section: Discussionmentioning

confidence: 99%

Therapy of Chagas Disease: Implications for Levels of Prevention

Sosa-Estáni

Colantonio

Segura

2012

Journal of Tropical Medicine

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“…The role of stem cells in the tissue regeneration is an important issue. An agent-based computational model has been proposed in [115] to investigate the regeneration of the chronic chagasic cardiomyopathy after bone marrow stem cell transplantation. The model includes inflammatory cell, fibrosis area, cardiomyocyte, proinflammatory cytokine tumor necrosis factor-α, Trypanosoma cruzi parasite and bone marrow stem cell.…”

Section: Agent-based Modelsmentioning

confidence: 99%

Towards a unified approach in the modeling of fibrosis: A review with research perspectives

Amar

Bianca

2016

Physics of Life Reviews

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Pathological fibrosis is the result of a failure in the wound healing process. The comprehension and the related modeling of the different mechanisms that trigger fibrosis is a challenge of many researchers that work in the field of medicine and biology. The modern scientific analysis of a phenomenon generally consists of three major approaches: theoretical, experimental, and computational. Different theoretical tools coming from mathematics and physics have been proposed for the modeling of the physiological and pathological fibrosis. However a complete framework is missing and the development of a general theory is required. This review aims at finding a unified approach in the modeling of fibrosis diseases that takes into account the different phenomena occurring at each level: molecular, cellular and tissue. Specifically by means of a critical analysis of the different models that have been proposed in the mathematical, computational and physical biology, from molecular to tissue scales, a multiscale approach is proposed, an approach that has been strongly recommended by top level biologists in the past decades.

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“…For example, computational models have predicted the effect of bone marrow stem cell transplantation on fibrosis in the cardiomyopathy associated with Chagas disease (Galvao et al 2008) or platelet activation after implantation of a bioprosthetic heart valve (Sirois and Sun 2010). The McCulloch group has published diverse computational models to study cardiac behavior, ranging from a model of focal myofibril disarray to represent regional septal dysfunction as seen in hypertrophic cardiomyopathy (Usyk et al 2001), to the effect of biventricular pacing on left ventricular function (Kerckhoffs et al 2009) and the influence of myosin regulatory proteins on myosin kinetics (Sheikh et al 2012).…”

Section: Computationalmentioning

confidence: 99%

Model Systems for Cardiovascular Regenerative Biology

Garbern

Mummery

Lee

2013

Cold Spring Harbor Perspectives in Medicine

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There is an urgent clinical need to develop new therapeutic approaches to treat heart failure, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of biological mechanisms of cardiac regeneration as well as to test therapeutic approaches to regenerate tissue and restore cardiac function following injury. An ideal model system should be inexpensive, easily manipulated, easily reproducible, physiologically representative of human disease, and ethically sound. In this review, we discuss computational, cell-based, tissue, and animal models that have been used to elucidate mechanisms of cardiovascular regenerative biology or to test proposed therapeutic methods to restore cardiac function following disease or injury.

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Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation

Abstract: The source code of our software is available online at www.vivas.ufba.br/bone/bone.zip .br Supplementaty information: Supplementary data are available at Bioinformatics online.

Cited by 17 publications

References 23 publications

Therapy of Chagas Disease: Implications for Levels of Prevention

Therapy of Chagas Disease: Implications for Levels of Prevention

Towards a unified approach in the modeling of fibrosis: A review with research perspectives

Model Systems for Cardiovascular Regenerative Biology

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