Development of a Topical Formulation Containing S. Lutea Extract: Stability, In Vitro Studies and Cutaneous Permeation

Abstract

Flavonoids have been widely incorporated into cosmetic and dermatological formulations, affording benefits such as antioxidant action, improved skin tone and fewer lines and wrinkles. Brazil has a huge biodiversity, with one of the richest flora in the world, and existing studies justify the quest for greater research efforts in this area. The cajazeira (Spondias lutea L.), a plant of the Anacardiaceae family from tropical America, is widely disseminated in Brazil. This plant was chosen because of the presence of flavonoids that exhibit antioxidant activity. The purpose of this research was to develop a stable topical formulation containing Spondias lutea extract with the aim of preventing skin diseases caused by UV radiation. Hydro ethanolic extract of Spondias lutea fruit was prepared and assayed for its the flavonoids content. The antioxidant activity was estimated by DPPH and superoxide assay. The physicochemical stability and skin permeation of the cream containing 8% (w/w) of extract were assessed. The results showed that the S. lutea extract possessed antioxidant activity, and that it is possible to obtain a stable cosmetic containing the extract, which is able to penetrate the skin. Thus, it is possible to use this extract to produce an anti-aging cosmetic.

In Vitro and Antioxidant Evaluation of a Nanoemulsion Formulation Containing Kojic Monooleate for Hyperpigmentation Treatment

“…Flavonoids are a class of phenolic compounds. Therefore, flavonoid content will be lower than phenolic content, and this supports the result obtained for both TFC and TPC of the KMO formulation and the control formulation, as the KMO formulation and the control formulation had phenolic content higher than total flavonoid content [24]. Correlations between antioxidant activity, DPPH inhibition and TFC would be lower than those of TPC, as the aluminium chloride method is specific to detect flavones and flavonols only.…”

“…Higher total phenolic content indicates higher antioxidant activity [21][22]. Flavonoids are secondary metabolites from plants that exhibit antioxidant, anti-inflammatory, and antibacteria activities [23][24]. The compounds contain high phenolic antioxidants such as kojic acid, vitamin C and niacinamide, often used in cosmetic products as a defense against free radicals [25].…”

Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties

“…Although rutin permeated the skin, the compound was also found in the stratum corneum (3.27 ± 1.92 μg/mL) by tape stripping test and in higher concentration in the retention test (114.68 ± 8.70 μg/mL). Studies performed by Chuang et al [75] and Isaac et al [76] showed release and deposit of flavonoids when incorporated in topical formulations. Moreover, Chuang et al [75] determined that the viable skin, specially the stratum corneum, could be a barrier delaying flavonoid permeation by enhancing compound deposition.…”

A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. Florida Prince: A New Solid Lipid Nanoparticle Cosmeceutical Formulation for Skincare

“…One of the most important phytoconstituents in medicinal plants are polyphenols, in particular flavonoids. Flavonoids are a class of plant secondary metabolites with great cosmetic potential due to their excellent antioxidant, anti-inflammatory and antibacterial activities [ 54 ]. In addition, flavonoids have been suggested in treating the signs of aging by different mechanisms including their antioxidant properties by free radical scavenging and metal chelation with metalloenzymes providing antiprotease activities [ 55 ], sunscreen effect, and restoration of UV-induced DNA damage [ 56 ].…”