Development of a Tacrolimus-loaded carboxymethyl chitosan scaffold as an effective 3D-printed wound dressing

Al-Hashmi, Sulaiman; Vakilian, Saeid; Jamshidi-adegani, Fatemeh; Al-Kindi, Juhaina; Al-Fahdi, Fahad; Al-Hatmi, Abdullah M.S.; Al-Jahdhami, Habib; Anwar, Muhammad U.; Al-Wahaibi, Nasar; Shalaby, Asem; Al-Harrasi, Ahmed

doi:10.1016/j.jddst.2023.104707

Cited by 7 publications

(3 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with 3D scaffolds, the hydrolysis performance of CA@3D scaffolds did not change significantly, which indicated that the addition of CA extract had negligible effects on the bio‐ink. Based on previous studies, [ 30,34 ] it is reasonable to maintain the degradation rate of CA @ 3D scaffolds at 60%–70% of their initial mass (Figure 1E).…”

Section: Resultsmentioning

confidence: 69%

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

Wang,

Zhang,

Song

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

How to promote wound healing is still a major challenge in the healthcare while macrophages are a critical component of the healing process. Compared to various bioactive drugs, many plants have been reported to facilitate the wound healing process by regulating the immune response of wounds. In this work, a 3D printed hydrogel scaffold loaded with natural Centella asiatica extract (CA extract) is developed for wound healing. This CA@3D scaffold uses gelatin and sodium alginate with CA extract as bio‐ink for 3D printing. The CA extract contains a variety of bioactive compounds that make the various active ingredients in Centella asiatica work in concert. The printed CA@3D scaffold can fit the shape of wound, orchestrate the macrophages and immune responses within the wound, and promote wound healing compared to commercial wound dressings. The underlying mechanism of promoting wound healing was also illuminated by applying multi‐omic analyses. Moreover, the CA extract loaded 3D scaffold also showed great ability to promote wound healing in diabetic chronic wounds. Due to its ease of preparation, low‐cost, biosafety, and therapeutic outcomes, this work proposes an effective strategy for promoting chronic wound healing.This article is protected by copyright. All rights reserved

show abstract

Section: Resultsmentioning

confidence: 69%

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

Wang,

Zhang,

Song

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Histopathological assessments of the treated and untreated wounds established the efficiency of the TAC-CMC scaffold in improving angiogenesis, promoting epidermal regeneration, stimulating fibroblast proliferation, and modulating inflammatory reactions. 167 …”

Section: Chitosan-based Formulations For Wound Healingmentioning

confidence: 99%

Chitosan alchemy: transforming tissue engineering and wound healing

Pramanik,

Aggarwal,

Kadi

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…CMCS is vital in medical materials, food, environmental protection, and other fields [16][17][18]. Hashmi's group developed a Tacrolimus-loaded carboxymethyl chitosan medical scaffold with promising antibacterial activity for improving angiogenesis, fibroblast proliferation, and inflammation [19]. Zhao's team prepared a composite hydrogel containing oxidized pullulan polysaccharide and carboxymethyl chitosan that is injectable, self-healing, antibacterial, and pro-healing, making it suitable for protecting and treating open abdominal wounds [20].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups

Wang,

Guo,

Liang

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

A total of 16 novel carboxymethyl chitosan derivatives bearing quinoline groups in four classes were prepared by different synthetic methods. Their chemical structures were confirmed by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and elemental analysis. The antioxidant experiment results in vitro (including DPPH radical scavenging ability, superoxide anion radical scavenging ability, hydroxyl radical scavenging ability, and ferric reducing antioxidant power) demonstrated that adding quinoline groups to chitosan (CS) and carboxymethyl chitosan (CMCS) enhanced the radical scavenging ability of CS and CMCS. Among them, both N, O-CMCS derivatives and N-TM-O-CMCS derivatives showed DPPH radical scavenging over 70%. In addition, their scavenging of superoxide anion radicals reached more than 90% at the maximum tested concentration of 1.6 mg/mL. Moreover, the cytotoxicity assay was carried out on L929 cells by the MTT method, and the results indicated that all derivatives showed no cytotoxicity (cell viability > 75%) except O-CMCS derivative 1a, which showed low cytotoxicity at 1000 μg/mL (cell viability 50.77 ± 4.67%). In conclusion, the carboxymethyl chitosan derivatives bearing quinoline groups showed remarkable antioxidant ability and weak cytotoxicity, highlighting their potential use in food and medical applications.

show abstract

Development of a Tacrolimus-loaded carboxymethyl chitosan scaffold as an effective 3D-printed wound dressing

Cited by 7 publications

References 57 publications

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

Chitosan alchemy: transforming tissue engineering and wound healing

Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups

Contact Info

Product

Resources

About