Development of a Supermolecular Radionuclide-Drug Conjugate System for Integrated Radiotheranostics for Non-small Cell Lung Cancer
Xinmiao Lu,
Yunyun Zhu,
Xiaohui Deng
et al.
Abstract:Radionuclide-drug conjugates (RDCs) designed from small molecule or nanoplatform shows complementary characteristics. We constructed a new RDC system with integrated merits of small molecule and nanoplatform-based RDCs. Erlotinib was labeled with 131 I to construct the bulk of RDC ( 131 I-ER). Floxuridine was mixed with 131 I-ER to develop a hydrogen bond-driving supermolecular RDC system ( 131 I-ER-Fu NPs). The carrier-free 131 I-ER-Fu NPs supermolecule not only demonstrated integrated merits of small molecul… Show more
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