Development of a superconducting rotating-gantry for heavy-ion therapy

Iwata, Y.; Noda, K.; Murakami, Takeshi; Shirai, Tomoyuki; Furukawa, Takuji; Fujita, Takeshi; Mori, Shinichiro; Mizushima, Kota; Shouda, K.; Fujimoto, T.; Ogitsu, T.; Obana, T.; Amemiya, Naoyuki; Orikasa, Takahiro; Takami, S.; Takayama, S.

doi:10.1016/j.nimb.2013.03.050

Cited by 30 publications

(15 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For heavier ions, costs are much higher as the gantry must accommodate particles with larger beam rigidities and added physical constraints introduce greater probability of errors ( 99 ). Currently there are only a few facilities which deliver carbon-ion beam therapy (CIBT) using a gantry: HIT, Heidelberg, Germany has a gantry which has a footprint of 6.5 m × 25 m (radius × length), weighing ~670 t ( 100 – 102 ) and HIMAC, QST, Japan has a SC gantry, 5.5 m × 13 m weighing ~300 t ( 103 , 104 ). A second generation, compact SC gantry with a smaller 4 m × 5.1 m footprint was also developed with Toshiba ( 105 ).…”

Section: Limitations and Avenues For Improvementsmentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

View full text Add to dashboard Cite

The physical and clinical benefits of charged particle therapy (CPT) are well recognized. However, the availability of CPT and complete exploitation of dosimetric advantages are still limited by high facility costs and technological challenges. There are extensive ongoing efforts to improve upon these, which will lead to greater accessibility, superior delivery, and therefore better treatment outcomes. Yet, the issue of cost remains a primary hurdle as utility of CPT is largely driven by the affordability, complexity and performance of current technology. Modern delivery techniques are necessary but limited by extended treatment times. Several of these aspects can be addressed by developments in the beam delivery system (BDS) which determines the overall shaping and timing capabilities enabling high quality treatments. The energy layer switching time (ELST) is a limiting constraint of the BDS and a determinant of the beam delivery time (BDT), along with the accelerator and other factors. This review evaluates the delivery process in detail, presenting the limitations and developments for the BDS and related accelerator technology, toward decreasing the BDT. As extended BDT impacts motion and has dosimetric implications for treatment, we discuss avenues to minimize the ELST and overview the clinical benefits and feasibility of a large energy acceptance BDS. These developments support the possibility of advanced modalities and faster delivery for a greater range of treatment indications which could also further reduce costs. Further work to realize methodologies such as volumetric rescanning, FLASH, arc, multi-ion and online image guided therapies are discussed. In this review we examine how increased treatment efficiency and efficacy could be achieved with improvements in beam delivery and how this could lead to faster and higher quality treatments for the future of CPT.

show abstract

Section: Limitations and Avenues For Improvementsmentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

View full text Add to dashboard Cite

show abstract

“…Next to the two clinically operating scanning rooms, a third scanning room with a rotating gantry, employing superconducting magnets to bend the carbon beam, has been installed . The use of the gantry is expected to be advantageous to further promote IMIT.…”

Section: Review Of Radiobiological Issues and Clinical Trialsmentioning

confidence: 99%

Radiobiological issues in prospective carbon ion therapy trials

Fossati

Matsufuji²,

Kamada³

et al. 2018

Medical Physics

View full text Add to dashboard Cite

Carbon ion radiotherapy (CIRT) is developing toward a versatile tool in radiotherapy; however, the increased relative biological effectiveness (RBE) of carbon ions in tumors and normal tissues with respect to photon irradiation has to be considered by mathematical models in treatment planning. As a consequence, dose prescription and definition of dose constraints are performed in terms of RBE weighted rather than absorbed dose. The RBE is a complex quantity, which depends on physical variables, such as dose and beam quality as well as on normal tissue‐ or tumor‐specific factors. At present, three RBE models are employed in CIRT: (a) the mixed‐beam model, (b) the Microdosimetric Kinetic Model (MKM), and (c) the local effect model. While the LEM is used in Europe, the other two models are employed in Japan, and unfortunately, the concepts of how the nominal RBE‐weighted dose is determined and prescribed differ significantly between the European and Japanese centers complicating the comparison, transfer, and reproduction of clinical results. This has severe impact on the way treatments should be prescribed, recorded, and reported. This contribution reviews the concept of the clinical application of the different RBE models and the ongoing clinical CIRT trials in Japan and Europe. Limitations of the RBE models and the resulting radiobiological issues in clinical CIRT trials are discussed in the context of current clinical evidence and future challenges.

show abstract

“…Originally proposed as a method to reduce the size of carbonion gantries, a number of researchers have developed solutions based on novel magnet designs. For example, NIRS have developed a cryogen-free rotatable superconducting dipole-quadrupole magnet for their carbon-ion gantry [116,117] ( Figure 6), and similar developments are in progress at Lawrence Berkeley Laboratory aimed both at carbon ions and at protons [118]. These designs are often adaptations of the Pavlovic-style gantry optics [119] utilised for example at Paul Scherrer Institute [120] (Figure 7), HIT [68] and other locations, but another trend is the use of modular achromatic optics.…”

Section: Recent Trends and Developmentsmentioning

confidence: 99%

Current and future accelerator technologies for charged particle therapy

Owen

Lomax

Jolly

2016

Nuclear Instruments and Methods in Physics Research Section A:

View full text Add to dashboard Cite

The past few years have seen significant developments both of the technologies available for proton and other charged particle therapies, and of the number and spread of therapy centres. In this review we give an overview of these technology developments, and outline the principal challenges and opportunities we see as important in the next decade. Notable amongst these is the ever-increasing use of superconductivity both in particle sources and for treatment delivery, which is likely to greatly increase the accessibility of charged particle therapy treatments to hospital centres worldwide.

show abstract

Development of a superconducting rotating-gantry for heavy-ion therapy

Cited by 30 publications

References 4 publications

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Radiobiological issues in prospective carbon ion therapy trials

Current and future accelerator technologies for charged particle therapy

Contact Info

Product

Resources

About