Development of a standardized combined plant extract containing nutraceutical formulation ameliorating metabolic syndrome components

Abstract

Plant bioactives have a great role in combating multifactorial disease conditions like metabolic syndrome (MetS). This research work aims to develop a standardized plant extract combination and formulate it to tablets with nutraceutical potentials. The extract was prepared from the bark powder of Ficus religiosa, seed powder of Syzigium cumini and leaf powder of Ocimum bacilicum chemometrically optimized in the ratio of 1.15:1.15:1.68 (Ashwattha: Jamun: Basil or FR: SC: OB). It is enriched in screened and pharmacologically active plant secondary metabolites. The tablets were prepared by direct compression using single-punch tablet machines. The nutraceutical tablets passed all the prescribed quality control tests with a justified pharmacokinetic profile. Results of animal experimentations have shown the hypoglycemic, hypolipidemic effect and antihypertensive effect of the nutraceutical tablets in relevant animal models. Thus, the nutraceutical formulation that showed effectivity in combating MetS can be opted as an adjunct therapy.

D-optimal Mixture Design for Optimized Microencapsulation of Vitamin A Palmitate and Its Characterizations

“…An empirical modeling technique for finding out the relationship amongst set of experimental factors and observed results is Response Surface methodology (RSM). The sequential steps in RSM involves developing the polynomial equation, generation of statistically analyzed analysis of variance (ANOVA) table, generation of response surface plots with different combinations of input parameters, determining the optimal level from desirability analysis and confirmation test for validation [16][17][18][19].…”

“…Polydispersity index or PDI, encapsulation efficiency or EE, and particle size are the output variables. The trial runs provided in the software generated experimental layout was followed to carry out the lab experimentations [16][17][18][19][20]. The parameters PDI, EE and particle size were considered as the output variables.…”

“…The output variables were determined for each trial run. These experimental values were incorporated in the datasheet of the experimental layout generated by the software and the data were statistically analyzed by means of analysis of variance or ANOVA followed by generated models optimization by Design Expert generated desirability ramp function graphs [16][17][18][19][20]. During selection of the best optimized model, amongst three output variables EE or encapsulation efficiency was considered for optimizing the process parameters for the devised microencapsulation procedure for the fortificant (VAP).…”

“…As a outcome for the optimization of experimental process parameters with the aid of Design Expert software with subsequent lab experimentations, software generated tables were obtained on model adequacy, fit summary statistics of the devised model, statistical analysis for each of the out variables by ANOVA, and the software generated graphs include normal plot of residuals for studentized diagnostics, 3D surface plots the model graphs showing the experimental process parameters and the desirability ramp function graphs basing on which final process optimizations were done [16][17][18][19][20].…”

Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking

“…This significant obstacle that the medical community has been facing has instigated a much-needed shift in the treatment strategies that are currently being employed. A dramatic switch that favors multi-target therapeutics and herbo-synthetic combinations as complementary or sometimes even alternative therapy is being explored [ 1 ]. There is enough literature to support the claim that secondary metabolites derived from several plants are pharmacologically active and have been quite successful in treating a wide range of diseases [ 2 , 3 ].…”