Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof

Maschke, Angelika; Becker, Christian; Eyrich, Daniela; Kiermaier, Josef; Blunk, Torsten; Göpferich, Achim

doi:10.1016/j.ejpb.2006.08.008

Cited by 100 publications

(89 citation statements)

References 29 publications

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“…Determination of total and effective encapsulation efficiencies Total encapsulation efficienc y was determined (MASCHKE et al, 2007) modified as follows: 12.4 mL of chloroform (12.4 mL) was added to a test tube containing 200 mg of microparticles; it was agitated in a Cole-Parmer super mixer for 10 seconds and let to rest for 10 minutes, twice. After the resting period, 12.4 mL of distilled water was added and a new agitation performed in the super mixer for 1 minute, with a resting period of 10 minutes.…”

Section: Evaluation Of the Performance Of Lipid Microparticlesmentioning

confidence: 99%

Production and characterization of lipid microparticles produced by spray cooling encapsulating a low molar mass hydrophilic compound

et al. 2010

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The objective of this research was to produce and characterize lipid particles (MpLs) that may be used as carriers of high amounts of hydrophilic core and evaluate the influence of the core amount on the performance of lipid microparticles. The MpLs were produced by spray cooling from solid and liquid lipid mixtures (stearic and oleic fatty acids and partly hydrogenated vegetable fat) containing glucose solution as core and soy lecithin as surfactant. The performance of MpLs was evaluated by means of the effective amount of encapsulated core, the core amount present on the surface of MpLs (superficial glucose) and the core release profile in aqueous solution. Morphological observations showed that MpLs presented spherical shape and a rugged and continuous surface, and an average diameter between 25 and 32 µm. The effective amount of encapsulated core was greater than 78% for all formulations evaluated. Larger amounts of superficial glucose were found in formulations in which more concentrated glucose solutions were used, regardless of the glucose lipid-solution ratio. The release results showed that core retention was significantly influenced by the glucose solution concentration, whereas release modulation was influenced by the glucose lipid-solution ratio.

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Section: Evaluation Of the Performance Of Lipid Microparticlesmentioning

confidence: 99%

Production and characterization of lipid microparticles produced by spray cooling encapsulating a low molar mass hydrophilic compound

et al. 2010

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“…In recent years, there has been increasing interest in the study of polymer systems rheology, whether in the form of solutions or melts (1). Many pharmaceutical processes such as hot melt extrusion (2)(3)(4)(5) and spray congealing (6)(7)(8) and products such as solid dispersions (9,10), suppositories (11) and pessaries utilize polymer melts. The rheological properties of polymer melts in these processes, if uncontrolled, may lead to a blockage or high backpressure in the extrusion system, clogging of the spray delivery system or inadequate filling of melts into moulds, which often necessitate the termination of the process.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Impact of Hydroxypropyl Methylcellulose on the Viscosity of PEG Melt Suspensions Using Surface Plots and Principal Component Analysis

Heng

Chan

2014

AAPS PharmSciTech

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Abstract. An understanding of the rheological behaviour of polymer melt suspensions is crucial in pharmaceutical manufacturing, especially when processed by spray congealing or melt extruding. However, a detailed comparison of the viscosities at each and every temperature and concentration between the various grades of adjuvants in the formulation will be tedious and time-consuming. Therefore, the statistical method, principal component analysis (PCA), was explored in this study. The composite formulations comprising polyethylene glycol (PEG) 3350 and hydroxypropyl methylcellulose (HPMC) of ten different grades (K100 LV, K4M, K15M, K100M, E15 LV, E50 LV, E4M, F50 LV, F4M and Methocel VLV) at various concentrations were prepared and their viscosities at different temperatures determined. Surface plots showed that concentration of HPMC had a greater effect on the viscosity compared to temperature. Particle size and size distribution of HPMC played an important role in the viscosity of melt suspensions. Smaller particles led to a greater viscosity than larger particles. PCA was used to evaluate formulations of different viscosities. The complex viscosity profiles of the various formulations containing HPMC were successfully classified into three clusters of low, moderate and high viscosity. Formulations within each group showed similar viscosities despite differences in grade or concentration of HPMC. Formulations in the low viscosity cluster were found to be sprayable. PCA was able to differentiate the complex viscosity profiles of different formulations containing HPMC in an efficient and time-saving manner and provided an excellent visualisation of the data.

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“…Protein nanocapsules could be prepared by various emulsification methods, such as single/double emulsions [59,60], polymerization [61], phase separation/coacervation [62], spray drying/spray congealing [63,64] and ultrasonic emulsification [65].…”

Section: Protein Nanocapsulesmentioning

confidence: 99%

Smart Nanocontainers: Preparation, Loading/Release Processes and Applications

Nguyen¹,

Assadi²

2018

IJNTR

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Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof

Cited by 100 publications

References 29 publications

Production and characterization of lipid microparticles produced by spray cooling encapsulating a low molar mass hydrophilic compound

Production and characterization of lipid microparticles produced by spray cooling encapsulating a low molar mass hydrophilic compound

A Study on the Impact of Hydroxypropyl Methylcellulose on the Viscosity of PEG Melt Suspensions Using Surface Plots and Principal Component Analysis

Smart Nanocontainers: Preparation, Loading/Release Processes and Applications

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