2022
DOI: 10.1002/cite.202200088
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Development of a Single‐Use Device and an Associated Optical Measurement Method for Automated Magnetic Bioseparation

Abstract: In bioseparation, magnetic particles can be used for the adsorption of biomolecules. They can be selectively separated from multi-component suspensions with high-gradient magnetic separation (HGMS). A single-use HGMS separation chamber has been developed to avoid cross-contamination. As with fixed-bed adsorption, breakthrough occurs after a certain time. Subsequently, the magnetic particles that are then still further fed, are lost together with the biomolecules bound to them. In order to stop the HGMS process… Show more

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