Development of a simple method for quantitation of methanesulfonic acid at low ppm level using hydrophilic interaction chromatography coupled with ESI-MS

Huang, Zhanwen; Francis, R.; Zha, Yan; Ruan, Joan

doi:10.1016/j.jpba.2014.08.019

Cited by 19 publications

(4 citation statements)

References 27 publications

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“…Anion‐exchange interactions are therefore expected with an H 2 O‐rich mobile phase, while hydrophilic interactions are expected with a CH 3 CN‐rich composition, as reported in previous studies (Huang et al ., ). Representative chromatograms for KYNA and Cl‐KYNA on the triazole‐bonded stationary phase with the 60:40 mobile phase at pH 3.0 are shown in Fig.…”

Section: Resultsmentioning

confidence: 97%

“…Currently, several commercially marketed HILIC columns are available containing bonded stationary phases such as dihydroxypropyl (diol), amide, aminopropyl, cyano, sulfobetain and phosphorylcholine (Guo and Gaiki, 2011). In addition, a weakly basic, triazole-bonded stationary phase column (Cosmosil® HILIC) has been reported to be useful for separation of small organic acids, including highly acidic alkyl (methyl to octyl) sulfonic acids (Huang et al, 2015). The precise retention mechanism by the triazole-bonded column is not fully understood, but it has been suggested that either hydrophilic interactions at the polar surface or anion-exchange interactions with protonated triazole in the stationary phase may retain polar and ionic compounds, respectively.…”

Section: Introductionmentioning

confidence: 99%

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A high‐performance liquid chromatography assay with a triazole‐bonded column for evaluation of d‐amino acid oxidase activity

Iwasaki

Kashiwaguma

Nagashima

et al. 2015

Biomedical Chromatography

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Elution profiles of kynurenic acid (KYNA) and 7-chlorokynurenic acid (Cl-KYNA) were examined by high-performance liquid chromatography (HPLC) using a triazole-bonded stationary phase column (Cosmosil® HILIC) under isocratic elution of a mobile phase consisting of CH3 CN-aqueous 10 mm ammonium formate between pH 3.0 and 6.0. The capacity factors of KYNA and Cl-KYNA varied with both the CH3 CN content and the pH of the mobile phase. The elution order of KYNA and Cl-KYNA was reversed between the CH3 CN- and H2 O-rich mobile phases, suggesting that hydrophilic interactions and anion-exchange interactions caused retention of KYNA and Cl-KYNA in the CH3 CN- and H2 O-rich mobile phases, respectively. The present HPLC method using a triazole-bonded column and fluorescence detection (excitation 250 nm, emission 398 nm) was applied to monitor in vitro production of KYNA from d-kynurenine (d-KYN) by d-amino acid oxidase (DAO) using Cl-KYNA as an internal standard. A single KYNA peak was clearly observed after enzymatic reaction of d-KYN with DAO. Production of KYNA from d-KYN was suppressed by the addition of commercial DAO inhibitors. The present HPLC method can be used to evaluate DAO activity and DAO inhibitory effects in candidate drugs for the treatment of schizophrenia.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

A high‐performance liquid chromatography assay with a triazole‐bonded column for evaluation of d‐amino acid oxidase activity

Iwasaki

Kashiwaguma

Nagashima

et al. 2015

Biomedical Chromatography

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“…MS has become an effective detection technique due to its high sensitivity and selectivity (27). The fragment of CTC was obtained with the ESI interface in both positive and negative ion modes.…”

Section: -mentioning

confidence: 99%

Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability

et al. 2020

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The aim of this work is to improve the solubility and bioavailability of chlortetracycline and the function of the immune response. Chlortetracycline bisulfate and chlortetracycline mesylate were successfully synthesized and characterized with several techniques, including spectroscopy, chromatography and mass spectrometry, which demonstrated that the C4-dimethylamino group of chlortetracycline can accept a proton from sulfuric acid and methanesulfonic acid to form the corresponding salts. In addition, chlortetracycline bisulfate and chlortetracycline mesylate were more soluble in water than chlortetracycline hydrochloride, but the antibacterial activity was not enhanced. The influences of chlortetracycline hydrochloride, chlortetracycline bisulfate and chlortetracycline mesylate on chlortetracycline and immunoglobulin concentrations in mouse serum were also investigated. These results suggested that the chlortetracycline bisulfate and chlortetracycline mesylate have good bioavailability and strong immune response and have potential applications in animal breeding and formulation technologies.

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“…Using a chiral fluorescence reagent, ( R )‐4‐(3‐isothiocyanatopyrrolidin‐1‐yl)‐7‐( N , N ‐dimethylaminosulfonyl)‐2,1,3‐benzoxadiazole (DBD‐PyNCS), we recently found that the l ‐Trp and l ‐KYN derivatives can be detected with high sensitivity by high‐performance liquid chromatography (HPLC) with a triazole‐bonded column (Cosmosil HILIC) and tandem mass‐spectrometric (MS/MS) detection. The column contains a unique stationary phase that induces hydrophilic or ion‐exchange interactions with polar compounds.…”

Section: Introductionmentioning

confidence: 99%

Chromatographic profiles of tryptophan and kynurenine enantiomers derivatized with (S)‐4‐(3‐isothiocyanatopyrrolidin‐1‐yl)‐7‐(N,N‐dimethylaminosulfonyl)‐2,1,3‐benzoxadiazole using LC–MS/MS on a triazole‐bonded column

et al. 2017

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d- and l-Tryptophan (Trp) and d- and l-kynurenine (KYN) were derivatized with a chiral reagent, (S)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole (DBD-PyNCS), and were separated enantiomerically by high-performance liquid chromatography (HPLC) equipped with a triazole-bonded column (Cosmosil HILIC) using tandem mass spectrometric (MS/MS) detection. Effects of column temperature, salt (HCO NH ) concentration, and pH of the mobile phase in the enantiomeric separation, followed by MS detection of (S)-DBD-PyNCS-d,l-Trp and -d,l-KYN, were investigated. The mobile phase consisting of CH CN/10 mM ammonium formate in H O (pH 5.0) (90/10) with a column temperature of 50-60 °C gave satisfactory resolution (Rs) and mass-spectrometric detection. The enantiomeric separation of d,l-Trp and d,l-KYN produced Rs values of 2.22 and 2.13, and separation factors (α) of 1.08 and 1.08, for the Trp and KYN enantiomers, respectively. The proposed LC-MS/MS method provided excellent detection sensitivity of both enantiomers of Trp and KYN (5.1-19 nM).

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Development of a simple method for quantitation of methanesulfonic acid at low ppm level using hydrophilic interaction chromatography coupled with ESI-MS

Cited by 19 publications

References 27 publications

A high‐performance liquid chromatography assay with a triazole‐bonded column for evaluation of d‐amino acid oxidase activity

A high‐performance liquid chromatography assay with a triazole‐bonded column for evaluation of d‐amino acid oxidase activity

Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability

Chromatographic profiles of tryptophan and kynurenine enantiomers derivatized with (S)‐4‐(3‐isothiocyanatopyrrolidin‐1‐yl)‐7‐(N,N‐dimethylaminosulfonyl)‐2,1,3‐benzoxadiazole using LC–MS/MS on a triazole‐bonded column

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