Development of a Simple and Reproducible Cell-derived Orthotopic Xenograft Murine Model for Neuroblastoma
KATHLEEN DOYLE,
ABD-ELRAHMAN HASSAN,
MARIA SUTTER
et al.
Abstract:Background/Aim: Neuroblastoma is a common childhood cancer with poor survival for children with highrisk disease, and ongoing research to improve outcomes is needed. Patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM) are reliable models for oncologic research; however, they are resource-intensive, expensive, and require significant expertise to develop and maintain. We developed an orthotopic xenograft murine model of neuroblastoma that utilizes cryopreserved banks of human neurobl… Show more
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