Development of a Short Version of the Thyroid-Related Patient-Reported Outcome ThyPRO

Abstract

A 39-item version of the ThyPRO, with good measurement properties, was developed and is recommended for clinical use.

Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism

“…The secondary outcomes included changes from baseline in generic health-related quality of life (as assessed by the EuroQoL [EQ] Group 5-Dimension Self-Report Questionnaire [EQ-5D]; scores on the EQ-5D descriptive index range from −0.59 to 1.00, and scores on the EQ visualanalogue scale range from 0 to 100, with higher scores indicating better quality of life), 16 comprehensive thyroid-related quality of life (as assessed by the ThyPRO-39 score, a shorter version of the ThyPRO measure, 17 at final follow-up only), handgrip strength (as assessed by means of the Jamar isometric dynamometer, with the recorded score as the best of three measures in the dominant hand), 18 executive cognitive function (as assessed with the letter-digit coding test, which indicates the speed of processing according to the number of correct responses in matching nine letters with nine digits in 90 seconds; minimum score, 0, with higher scores indicating better executive cognitive function; there is no maximum score), 19 blood pressure (systolic and diastolic), weight, body-mass index, waist circumference, activities of daily living (as assessed by the Barthel Index of functional levels in activities of daily living, on a scale ranging from 0 to 20, with higher scores indicating better performance), 20 the Instrumental Activities of Daily Living score (on a scale from 0 to 14, with higher scores indicating better performance in activities of daily living), 21 and fatal and nonfatal cardiovascular events. The minimum follow-up was 1 year, and the maximum follow-up was 3 years.…”

ThyPROgr: the Greek edition of the ThyPRO questionnaires for patients with benign thyroid diseases

“…These DIF have been identified previously and are not considered as cross-cultural invalidity but rather a consequence of minor violations of the unidimensionality assumption of the scale. The developers have accepted this minor violation because it reveals other desirable features of the instrument, e.g., ability to discriminate among the less impacted patients (minimizing ceiling effects) [12] and because factor analyses have confirmed an overall onefactor solution as dominant [34]. Since ThyPRO-39 is the version generally recommended for use in international multicenter studies, DIF in other items in that version is of concern.…”

“…ThyPRO has been widely used to assess thyroid-related quality of life in patients with thyroid diseases [9][10][11]. Recently, an abbreviated version (39 items) of the ThyPRO (ThyPRO-39), with good measurement properties was developed and is recommended for clinical use as an alternative to the original version [12].…”

Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism

“…The trial included a sufficient number of participants to provide good statistical power to show no benefits regarding symptoms. We used validated measures of thyroid-specific quality of life that have been shown to be sensitive to change, 14,17 as well as a range of secondary outcomes of clinical relevance. However, the trial also had certain limitations.…”