Development of a sensitive voltammetric sensor for diltiazem determination in biological samples using MWCNT/PPy-PBA modified glassy carbon electrode

Ostovar, Sahar; Maghsoudi, Shahab; Mousavi, Mehdi

doi:10.1016/j.synthmet.2021.116928

Cited by 10 publications

(5 citation statements)

References 52 publications

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“…These results specified that during hydrothermal method the GO was reduced to r-GO. 34 The combined graph in this figure showed that after reduction of graphene oxide to reduce graphene oxide the absorption peaks of different oxygen containing group is reduced and some disappeared. It confirmed that GO changed into reduced graphene oxide effectively.…”

Section: Resultsmentioning

confidence: 91%

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Ag-rGO Nanocomposite as an Efficient Electrochemical Sensor for Thiourea

Shafi¹,

Bahader²,

GUL³

et al. 2022

ECS Adv.

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The nanofabrication of composite-based sensors can be seen in the research literature, but high price restricts their use on a wider scale in the developing world. Here, we report their use for the detection of thiourea (TU), a well-known carcinogen. Briefly, reduced graphene (r-GO) sheets with silver (Ag) nanoparticles impregnated were prepared via hydrothermal and chemical reduction method. The synthesized nano-composite material was characterized by various physiochemical techniques like Fourier transform infrared spectroscopy, X-ry diffraction, scanning electronmicroscopy, and cyclic voltammetry (CV) and applied as synthesized for the detection and sensing of TU. The Ag-rGO changed electrode enhanced approximately three times greater anodic current compared to rGO and five times greater anodic current compared to GCE. Electrical and catalytic oxidation of TU was achieved by GCE, GO, rGO, and Ag-rGO at 0.2 to 0.25 V applying CV. The concentrations used were 10 to 50 µM, while the current at anode increased as the concentration increased. The anodic current is increased by an increasing scan rate of 20, 40, 60, 80, and 100 mV/s, so it could be used for recognition of TU in real time sample with good sensitivity, stability and reproducibility.

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Section: Resultsmentioning

confidence: 91%

“…5 the sample (A,B) (rGO) displayed stacked sheets which made logic that these are the rGO layers having superior surface space as compare to graphene oxide. 34 The nanomaterial surface study was checked by SEM where silver nanoparticles appeared on the sheets of rGO exposed in Fig. 5 (C,D) (Ag-rGO).…”

Section: Resultsmentioning

confidence: 99%

Ag-rGO Nanocomposite as an Efficient Electrochemical Sensor for Thiourea

Shafi¹,

Bahader²,

GUL³

et al. 2022

ECS Adv.

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“…To obtain optimal conductive polypyrrole−based polymeric film, one needs to ensure suitable adhesion of the monomer to the substrate. MWCTN was employed as a substrate for the electropolymerization process; this material was chosen because it has been shown to improve the electrical properties of the sensor, in addition to providing strong adsorption and enhancing surface reaction activity [ 44 ]. An analysis was conducted in order to evaluate the optimal amount of MWCNT (1 mg/mL) to be added to the electrode surface ( Figure S1 ); the result obtained from this analysis pointed to an optimal MWCNT concentration of 7 µL.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic Material for Quantification of Methotrexate Using Sensor Based on Molecularly Imprinted Polypyrrole Film and MWCNT/GCE

et al. 2023

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This study investigates biomimetic sensors for the detection of methotrexate contaminants in environmental samples. Sensors inspired by biological systems are the focus of this biomimetic strategy. Methotrexate is an antimetabolite that is widely used for the treatment of cancer and autoimmune diseases. Due to the widespread use of methotrexate and its rampant disposal into the environment, the residues of this drug are regarded as an emerging contaminant of huge concern, considering that exposure to the contaminant has been found to lead to the inhibition of some essential metabolic processes, posing serious risks to humans and other living beings. In this context, this work aims to quantify methotrexate through the application of a highly efficient biomimetic electrochemical sensor constructed using polypyrrole−based molecularly imprinted polymer (MIP) electrodeposited by cyclic voltammetry on a glassy carbon electrode (GCE) modified with multi−walled carbon nanotubes (MWCNT). The electrodeposited polymeric films were characterized by infrared spectrometry (FTIR), scanning electron microscopy (SEM), and cyclic voltammetry (CV). The analyses conducted using differential pulse voltammetry (DPV) yielded a detection limit of 2.7 × 10−9 mol L−1 for methotrexate, a linear range of 0.01–125 μmol L−1, and a sensitivity of 0.152 μA L mol−1. The results obtained from the analysis of the selectivity of the proposed sensor through the incorporation of interferents in the standard solution pointed to an electrochemical signal decay of only 15.4%. The findings of this study show that the proposed sensor is highly promising and suitable for use in the quantification of methotrexate in environmental samples.

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“…The operational pH range of the constructed sensor was checked for 1.0 × 10 −3 and 1.0 × 10 −4 mol L −1 DTZ solutions over a wide pH range (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The constructed sensor showed very slight potential uctuations in a pH range of 2.0-8.0 (Fig.…”

Section: Effect Of Phmentioning

confidence: 99%

“…2 As a result, it is essential to closely monitor the DTZ level in pharmaceutical doses and biological fluids when using this medication. It has been reported that DTZ can be detected in its solutions using a variety of analytical techniques, including high performance liquid chromatography (HPLC), 3 gas chromatography, 4 high performance thin layer chromatography (HPTLC), 5 spectrophotometry, 6 voltammetry 7–9 and potentiometry. 10 Most of the aforementioned techniques have plenty of limitations, including the requirement for expensive equipment, the need for earlier time-consuming treatment or derivatization reactions and their inapplicability to colored and turbid drug sample solutions.…”

Section: Introductionmentioning

confidence: 99%