“…Several methods have been reported to determine lacosamide as a single analyte (Devi, Varma, Rani, & Srinivas, 2014; D'Urso, Ricotta, & de Grazia, 2017; Kestelyn et al, 2011; Kim, Koo, et al, 2012; Korman, Langman, & Jannetto, 2015; Martinez et al, 2012; Nikolaou, Papoutsis, Spiliopoulou, Voudris, & Athanaselis, 2015; Shah, Vasantharaju, Arumugam, Muddukrishna, & Desai, 2012), with its major metabolite desmethyl lacosamide (Payto, Foldvary‐Schaefer, So, Bruton, & Wang, 2014), and in presence of other AEDs (Deeb et al, 2014; Gonçalves, Alves, Bicker, Falcão, & Fortuna, 2018; Kuhn & Knabbe, 2013) in various biological matrices. Different analytical techniques such as immunoassay (D'Urso et al, 2017), GC–MS (Nikolaou et al, 2015), HPLC with ultraviolet detection (Devi et al, 2014; Kestelyn et al, 2011; Martinez et al, 2012; Shah et al, 2012), photodiode array detection (Gonçalves et al, 2018), and MS/MS (Deeb et al, 2014; D'Urso et al, 2017; Kim, Gu, et al, 2012; Korman et al, 2015; Payto et al, 2014) have been used for its determination. Kuhn and Knabbe (2013) have reported a UPLC–MS/MS method for the simultaneous measurement of six AEDs in serum and plasma samples.…”