Development of a Self‐Adhesive Oleogel Formulation Designed for the Slow Release of Semiochemicals

Abstract

Oleogels have been widely studied as delivery matrices for lipophilic compounds. Despite their potential, oleogels are underexplored for the formulation and release of semiochemicals for insect behavior manipulation strategies. An ethylcellulose-candelilla wax-oleogel as a suitable carrier for the slow release of volatile semiochemicals, employing the sesquiterpene 𝜷-caryophyllene as a model substance is presented. A current drawback of ethylcellulose oleogels is the high temperature needed during the oleogel preparation procedure, leading to excessive volatilization of the active compounds. Reducing the gelling temperature from 104.8 to 66.9 °C and, thus, the volatile addition temperature by addition of the softener octyldodecanol results in 95.28% entrapment efficiency. Experimental results demonstrate release modifiability by tailoring the matrix crystalline state due to candelilla wax addition. Furthermore, a method is established for analyzing the self-adhesive properties of the gel on plant leaves. In addition, the gel's self-adhesive properties employed on apple leaves are synergistically affected by oil leakage and gel stiffness. Olfactometer experiments showed that the formulation is able to enhance the attractiveness of aphid-infested plants for parasitic wasps. The present study provides a novel matrix-type semiochemical formulation based on non-toxic, biobased and biodegradable materials and will contribute to the establishment of oleogels as delivery systems for semiochemicals.

Effect of Soy Wax/Rice Bran Oil Oleogel Replacement on the Properties of Whole Wheat Cookie Dough and Cookies

“…The presence of very high amounts of oleogel can be the reason for this. It has been previously reported that oleogels form strong interactions with the interacting surfaces, thereby promoting adhesion [54].…”

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

“…[14][15][16][17][18] Among them, the dissolution DOI: 10.1002/mame.202300361 of poorly water-soluble drugs and their related controlled release profiles are drawing increasing attention. [19][20][21][22] Particularly, the fast or pulsatile release, one type of ratecontrolled release profile (Figure 1), has the advantages of rapid release for achieving a rapid therapeutic action for many diseases such as fever, aches, and emotional irritability. [23][24][25] During the past three decades, the giant progress of nanoscience and nanotechniques has provided many useful strategies for enhancing the dissolution and effective delivery of poorly water-soluble drugs.…”

“…[ 14–18 ] Among them, the dissolution of poorly water‐soluble drugs and their related controlled release profiles are drawing increasing attention. [ 19–22 ] Particularly, the fast or pulsatile release, one type of rate‐controlled release profile ( Figure ), has the advantages of rapid release for achieving a rapid therapeutic action for many diseases such as fever, aches, and emotional irritability. [ 23–25 ]…”