Development of a Selective and Sensitive Chlorogenic Acid Fluorimetric Sensor Using Molecularly Imprinted Polymer ZnO Quantum Dots

Haghani, Sahar Khaksar; Ensafi, Ali A.; Kazemifard, Nafiseh; Rezaei, Behzad

doi:10.1109/jsen.2020.2972040

Cited by 12 publications

(2 citation statements)

References 22 publications

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“…After 20 min, the ZnO-QDs were obtained. The obtained QDs were washed several times with ethanol and freeze dried to get the QDs powder that stored for subsequent applications [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

"Off/On” Fluorescent Probe based on Aggregation-Induced Quenching of ZnO-Quantum dots for Determination of Ara-C: Pharmacokinetic Applications, Adsorption Kinetics & Green Profile Assessment

et al. 2023

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Herein, a turn “Off/On” fluorescence probe based on ZnO quantum dots (ZnO-QDs) has been proposed and successfully utilized for the determination of Ara-C (cytarabine) using ceric ions (Ce4+) as quencher and ethylenediamine (ED) as a linker. The probe is based initially on the quenching effect of Ce4+ ions on the strong native fluorescence of ZnO-QDs forming the Turn Off system (Ce@ZnO-QDs) that believed to occur due to the aggregation-induced quenching (AIQ) mechanism. The second step is the addition of Ara-C in the presence of ethylenediamine (ED) that encourages the formation of Ara-C/ED/Ce4+ as well as the release of the free ZnO-QDs, leading to the recovery of the fluorescence intensity. The developed sensing platform shows a linear response towards Ara-C over the range of 10 to 1000 ng mL−1 giving a limit of detection (LOD) and limit of quantitation (LOQ) of 1.22 ng mL−1 and 3.70 ng mL−1, respectively. A dispersive magnetic solid phase micro-extraction (dMSPE) method was developed and optimized for the extraction of Ara-C in spiked human plasma using thiol-modified magnetite nanoparticles (S-MNPs). The proposed platform exhibits good sensitivity toward Ara-C in the presence of different interfering substances. Excellent recoveries are obtained after spiking different concentrations of Ara-C into rabbit plasma samples. The validated experimental parameters have been successfully applied to monitor the pharmacokinetic profile of Ara-C in rabbit plasma. A detailed adsorption kinetics study has been carried out to provide a deep insight into the adsorption behavior of Ara-C on the thiol-doped-magnetite nanoparticles. The greenness assessment of the proposed method was achieved and compared with other reported methods using two tools of greenness; the green analytical procedure index (GAPI) and the analytical greenness calculator AGREE.

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“…After 20 min, the ZnO-QDs were obtained. The obtained QDs were washed several times with ethanol and freeze dried to get the QDs powder that stored for subsequent applications [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

"Off/On” Fluorescent Probe based on Aggregation-Induced Quenching of ZnO-Quantum dots for Determination of Ara-C: Pharmacokinetic Applications, Adsorption Kinetics & Green Profile Assessment

et al. 2023

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“…1,2 However, the presence of excess chlorogenic acid can cause stress reactions such as nausea and vomiting, and diseases such as inflammation and dermatitis in human beings. 3,4 Therefore, it is important to determine unknown concentrations of chlorogenic acid in environmental and biological systems via sensitive and rapid methods. Presently, multiple analytical methods including chromatography, 5,6 electrical analysis 7,8 and capillary electrophoresis 9 have been developed for the detection of chlorogenic acid.…”

Section: Introductionmentioning

confidence: 99%