“…Similarly, Antal and Hajdu (2014) proposed a strategy involving image-level quality assessment, pre-screening followed by lesion and anatomical features extraction to finally decide about the presence of DR using ensemble of classifiers. Further, for identification of different stages of DR features from morphological region properties (Yun et al, 2008), texture parameters (Acharya et al, 2012;Mookiah et al, 2013b), non-linear features of the higher-order spectra Acharya et al (2008), hybrid Dhara et al (2015) and information fusion (Niemeijer et al, 2009) approaches were found useful. As the DME is graded based on the location of the EXs from macula, many researchers (Giancardo et al, 2012;Medhi and Dandapat, 2014;Perdomo et al, 2016;Marin et al, 2018) proposed EXs based features to determine the severity of the DME.…”