Development of a robust SFC method for evaluation of compatibility for a novel antituberculotic fixed-dose combination

Petruševska, Valentina; Krtalić, Iva; Rašić, Andrea; Mornar, Ana

doi:10.1039/c9ay00117d

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Development of a robust SFC method for evaluation of compatibility for a novel antituberculotic fixed-dose combination

Abstract: A fast and simple supercritical fluid chromatography method for the simultaneous determination of two antituberculotic drugs, isoniazid and rifabutin, and their impurities from a new proposed fixed-dose combination (FDC) was developed.

Cited by 6 publications

References 34 publications

Application of SFC for the characterization of formulated drug products

Application of SFC for the characterization of formulated drug products

Retention mechanisms of imidazoline and piperazine-related compounds in non-aqueous hydrophilic interaction and supercritical fluid chromatography based on chemometric design and analysis

Supercritical fluid chromatography for pharmaceutical quality control: Current challenges and perspectives

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