Development of a Repertoire and a Food Frequency Questionnaire for Estimating Dietary Fiber Intake Considering Prebiotics: Input from the FiberTAG Project

Neyrinck, Audrey M.; Nazare, Julie‐Anne; Jottard, Romain; Dib, Sarah; Sothier, Monique; Berghe, Laurie Van Den; Alligier, Maud; Alexiou, Hélène; Maquet, Véronique; Vinoy, Sophie; Bischoff, Stephan C.; Walter, Jens; Laville, Martine

doi:10.3390/nu12092824

Cited by 15 publications

(12 citation statements)

References 30 publications

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“…Dietary fibers including soluble fibers, insoluble fibers, fructans, fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) were evaluated using a specific database from the FiberTAG project. 74 The results were expressed in quantities and in proportion of total energy intake (EI). The lipid intakes were also expressed in proportion of total fatty acids (FA).…”

Section: Methodsmentioning

confidence: 99%

Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients

et al. 2021

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Alcohol use disorder (AUD) is a chronic relapsing disease associated with malnutrition, metabolic disturbances, and gut microbiota alterations that are correlated with the severity of psychological symptoms. This study aims at supplementing AUD patients with prebiotic fiber during alcohol withdrawal, in order to modulate the gut microbiota composition and to evaluate its effect on gastrointestinal tolerance, metabolism, and patient’s behavior. A randomized, double-blind, placebo-controlled study included 50 AUD patients assigned to inulin versus maltodextrin daily supplementation for 17 days. Biological measurements (fecal microbial 16S rDNA sequencing, serum biology), dietary intake, validated psychological questionnaires, and gastrointestinal tolerance assessment were performed before and after the intervention. Inulin significantly decreased the richness and evenness and induced changes of 8 genera (q < 0.1) including Bifidobacterium and Bacteroides . Prebiotic had minor effects on gastrointestinal symptoms and nutritional intakes compared to placebo. All patients showed an improvement in depression, anxiety, and craving scores during alcohol withdrawal regardless of the intervention group. Interestingly, only patients treated with inulin significantly improved the sociability score and had an increased serum level of brain-derived neurotrophic factor. This pilot study shows that inulin is well tolerated and modulates the gut microbiota and the social behavior in AUD patients, without further improving other psychological and biological parameters as compared to placebo. Gut2Brain study, clinicaltrial.gov: NCT03803709, https://clinicaltrials.gov/ct2/show/NCT03803709

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Section: Methodsmentioning

confidence: 99%

Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients

et al. 2021

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“…This 1-week recall questionnaire has been designed to include vegetables particularly rich in fructans, as previously reported [27]. As compared to 24 h-recall method or food diaries, this questionnaire is more rapid and easy to complete and meets the objective to focus on fructan and DF intake [28]. Participants received a cookbook with recipes based on vegetables either rich or poor in fructans and were advised to consume at least one meal proposed in the recipe per day.…”

Section: Interventionmentioning

confidence: 99%

“…Energy and nutrient intakes were calculated from the 1-week recall using the Nubel Pro program (Nubel asbl, Brussels, Belgium). Fructan intake as well as fructan content of the recipes were calculated using the FiberTAG repertoire detailing prebiotic (oligo) saccharides (including fructans) in food products [28].…”

Section: Energy and Nutrient Intakesmentioning

confidence: 99%

“…The DF intake assessed by questionnaires (that does not consider the native inulin supplement) was not significantly modified in this subcohort. We calculated the average fructan content of recipes from both cookbooks using the FiberTAG repertoire detailing fructan content in food products [28]: it reached 11.2 ± 1.7 g per portion for the cookbook designed for prebiotic group versus 0.4 ± 0.1 g per portion for the cookbook designed for placebo group. Importantly, fructan intake estimated by using 1-week recall questionnaire was 3 times larger in the prebiotic group than the placebo group (independently of inulin supplement).…”

Section: Nutrient Intakementioning

confidence: 99%

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Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial

et al. 2021

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Purpose Inulin-type fructans (ITF) are prebiotic dietary fibre (DF) that may confer beneficial health effects, by interacting with the gut microbiota. We have tested the hypothesis that a dietary intervention promoting inulin intake versus placebo influences fecal microbial-derived metabolites and markers related to gut integrity and inflammation in obese patients. Methods Microbiota (16S rRNA sequencing), long- and short-chain fatty acids (LCFA, SCFA), bile acids, zonulin, and calprotectin were analyzed in fecal samples obtained from obese patients included in a randomized, placebo-controlled trial. Participants received either 16 g/d native inulin (prebiotic n = 12) versus maltodextrin (placebo n = 12), coupled to dietary advice to consume inulin-rich versus inulin-poor vegetables for 3 months, in addition to dietary caloric restriction. Results Both placebo and prebiotic interventions lowered energy and protein intake. A substantial increase in Bifidobacterium was detected after ITF treatment (q = 0.049) supporting our recent data obtained in a larger cohort. Interestingly, fecal calprotectin, a marker of gut inflammation, was reduced upon ITF treatment. Both prebiotic and placebo interventions increased the ratio of tauro-conjugated/free bile acids in feces. Prebiotic treatment did not significantly modify fecal SCFA content but it increased fecal rumenic acid, a conjugated linoleic acid (cis-9, trans-11 CLA) with immunomodulatory properties, that correlated notably to the expansion of Bifidobacterium (p = 0.031; r = 0.052). Conclusions Our study demonstrates that ITF-prebiotic intake during 3 months decreases a fecal marker of intestinal inflammation in obese patients. Our data point to a potential contribution of microbial lipid-derived metabolites in gastro-intestinal dysfunction related to obesity. ClinicalTrials.gov Identifier NCT03852069 (February 22, 2019 retrospectively, registered).

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“…The Block 2014 Food Frequency Questionnaire is not specifically tailored to quantify fermentable dietary fibers, and this raises the possibility of unrecognized relationships between diet and probiotic effect. Since completion of this trial, there have been efforts to develop and validate dietary indices that relate host diet to microbiome 58 , 59 and these should be leveraged in future studies.…”

Section: Discussionmentioning

confidence: 99%

Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study

Cabrera

Coren

Pant

et al. 2022

Sci Rep

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The incidence of type 1 diabetes (T1D) has increased, coinciding with lifestyle changes that have likely altered the gut microbiota. Dysbiosis, gut barrier dysfunction, and elevated systemic inflammation consistent with microbial antigen exposure, have been associated with T1D susceptibility and progression. A 6-week, single-arm, open-label pilot trial was conducted to investigate whether daily multi-strain probiotic supplementation could reduce this familial inflammation in 25 unaffected siblings of T1D patients. Probiotic supplementation was well-tolerated as reflected by high participant adherence and no adverse events. Community alpha and beta diversity were not altered between the pre- and post-supplement stool samplings. However, LEfSe analyses identified post-supplement enrichment of the family Lachnospiraceae, producers of the anti-inflammatory short chain fatty acid butyrate. Systemic inflammation was measured by plasma-induced transcription and quantified with a gene ontology-based composite inflammatory index (I.I.com). Post-supplement I.I.com was significantly reduced and pathway analysis predicted inhibition of numerous inflammatory mediators and activation of IL10RA. Subjects with the greatest post-supplement reduction in I.I.com exhibited significantly lower CD4+ CD45RO+ (memory):CD4+ CD45RA+ (naïve) T-cell ratios after supplementation. Post-supplement IL-12p40, IL-13, IL-15, IL-18, CCL2, and CCL24 plasma levels were significantly reduced, while post-supplement butyrate levels trended 1.4-fold higher. Probiotic supplementation may modify T1D susceptibility and progression and warrants further study.

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Development of a Repertoire and a Food Frequency Questionnaire for Estimating Dietary Fiber Intake Considering Prebiotics: Input from the FiberTAG Project

Cited by 15 publications

References 30 publications

Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients

Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients

Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial

Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study

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