Development of a realistic three-layer phantom for intravascular ultrasound (IVUS) imaging

Brunette, Jean; Mongrain, Rosaire; Durand, Louis-Gilles; Bertrand, Olivier; Laurier, Jean; Tardlf, J.C.

doi:10.1109/iembs.1999.804204

Cited by 6 publications

(9 citation statements)

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“…The geometric model used is an idealized model of a coronary artery (3.175 mm inner diameter, 10 cm length) presenting an eccentric stenosis with a 50% area reduction (16,17). Casts to create the lumen of the artery were made with a low melting point alloy (Cerrolow117 ™ , Cerro Metal Products).…”

Section: Model Preparationmentioning

confidence: 99%

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

et al. 2010

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Leukocytes play a pivotal role in the progression of atherosclerosis. A novel three dimensional in vitro asymmetric stenosis model was used to better investigate the role of local hemodynamics in the adhesion of leukocytes to an established plaque. The adhesion of a human promyelocytic cell line (NB4) on a human abdominal aortic endothelial cell (EC) monolayer was quantified. NB4 cells were circulated over TNF-α stimulated and non-stimulated ECs for 1 or 6 hrs at 1.25 or 6.25 dynes/cm 2 and compared to static conditions. Cytokine stimulation increased significantly endothelial cell expression of intercellular adhesion molecule and vascular cell adhesion molecule. Under static conditions, neutrophils adhered overall more than under flow, with decreased adhesion with increasing shear. Adhesion was significantly higher in the recirculation region distal to the stenosis than in the inlet. Preshearing the endothelial cells decreased the expression of cell adhesion molecules in inflamed endothelium and significantly decreased adhesion. However, the ratio of adhesion between the recirculation zone and the inlet increased, hence exhibiting an increased regional difference. This work suggests an important role for neutrophil-endothelial cell interactions in the atherosclerotic process, especially in wall shear gradient regions. This is important clinically, potentially helping to explain plaque stability.

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Section: Model Preparationmentioning

confidence: 99%

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

et al. 2010

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“…TMMs with good acoustical properties typically consist of appropriate scattering particles suspended in a water-based gelatin or agar material (Burlew 1980;Madsen et al 1978;Madsen 1986;Zagzebski 1991;Ryan and Foster 1997;Ramnarine et al 2001;Madsen et al 1982a;Bush and Hill 1983;Blechinger et al 1988). The use of cellulose scattering particles has been suggested (Rickey et al 1995) and used to develop an intravascular artery phantom (Brunette et al 2001) and flow phantom (Rickey et al 1995;Poepping et al 2002), although this TMM suffers from poor frequency-dependence of attenuation.…”

Section: Introductionmentioning

confidence: 97%

“…These are required for teaching and training, machine calibration and assessment of new imaging modalities. Anthropomorphic phantoms have been developed to simulate features of the breast (Madsen et al 1982b), abdomen Zagzebski et al 1991) and arteries (Ryan and Foster 1997;Brunette et al 2001;Gatzoulis et al 2003;Chu and Rutt 1997).…”

Section: Introductionmentioning

confidence: 99%

An anthropomorphic tissue-mimicking phantom of the oesophagus for endoscopic ultrasound

Inglis

Ramnarine

Plevris

et al. 2006

Ultrasound in Medicine & Biology

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“…The dimensions of the flow phantom were set to 10 × 10 × 10 cm (1000 cc) (1 l) (61 in. 3 ) to accommodate 3D imaging of the first three portal vein branches of a full scale Caucasian male liver. The flow phantom would be connected to inlet and outlet hoses to establish fluid flow through the phantom while the phantom rested on a laboratory table for ultrasound imaging, or, on the patient beds of MRI or CT systems.…”

Section: Iia Target Applicationmentioning

confidence: 99%

“…Many of the phantoms cited in literature are for "static" applications [1][2][3][4][5] that do not involve flowing fluids even if the phantom contains a fluid as a contrast or a calibration reference. Examples of static phantom types and their applications would be: solid phantoms imitating tissue layer density changes for needle stick training; agar or polymer filled phantoms used for ultrasound training or calibration; water or contrast filled acrylic cylinders used for MRI/CT scanner calibration.…”

Section: Purposementioning

confidence: 99%

An investigation of industrial molding compounds for use in 3D ultrasound, MRI, and CT imaging phantoms

et al. 2013

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Purpose: This study investigated the ultrasound, MRI, and CT imaging characteristics of several industrial casting and molding compounds as a precursor to the future development of durable and anatomically correct flow phantoms. Methods: A set of usability and performance criteria was established for a proposed phantom design capable of supporting liquid flow during imaging. A literature search was conducted to identify the materials and methods previously used in phantom fabrication. A database of human tissue and casting material properties was compiled to facilitate the selection of appropriate materials for testing. Several industrial casting materials were selected, procured, and used to fabricate test samples that were imaged with ultrasound, MRI, and CT. Results: Five silicones and one polyurethane were selected for testing. Samples of all materials were successfully fabricated. All imaging modalities were able to discriminate between the materials tested. Ultrasound testing showed that three of the silicones could be imaged to a depth of at least 2.5 cm (1 in.). The RP-6400 polyurethane exhibited excellent contrast and edge detail for MRI phantoms and appears to be an excellent water reference for CT applications. The 10T and 27T silicones appear to be usable water references for MRI imaging. Conclusions: Based on study data and the stated selection criteria, the P-4 silicone provided sufficient material contrast to water and edge detail for use across all imaging modalities with the benefits of availability, low cost, dimensional stability, nontoxic, nonflammable, durable, cleanable, and optical clarity. The physical and imaging differences of the materials documented in this study may be useful for other applications.

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Development of a realistic three-layer phantom for intravascular ultrasound (IVUS) imaging

Cited by 6 publications

References 0 publications

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

An anthropomorphic tissue-mimicking phantom of the oesophagus for endoscopic ultrasound

An investigation of industrial molding compounds for use in 3D ultrasound, MRI, and CT imaging phantoms

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