Development of a Rapid Cartilage Damage Quantification Method for the Lateral Tibiofemoral Compartment Using Magnetic Resonance Images: Data from the Osteoarthritis Initiative

Abstract

The purpose of this study was to expand and validate the cartilage damage index (CDI) to detect cartilage damage in the lateral tibiofemoral compartment. We used an iterative 3-step process to develop and validate the lateral CDI: development (100 knees), testing (80 knees), and validation (100 knees). The validation set included 100 knees from the Osteoarthritis Initiative that was enriched to include all grades of lateral joint space narrowing (JSN, 0–3). Measurement of the CDI was rapid at 7.4 (s.d. 0.73) minutes per knee pair (baseline and follow-up of one knee). The intratester reliability is good (intraclass correlation coefficient (3, 1 model) = 0.86 to 0.98). At baseline, knees with greater KL grade and lateral JSN had a lower mean CDI (i.e., greater cartilage damage). Baseline lateral CDI is associated with both lateral JSW (r = 0.81 to 0.85, p < 0.01) and HKA (r = −0.30 to −0.33, p < 0.05). The SRM is good (lateral femur SRM = −0.76; lateral tibia SRM = −0.73; lateral tibiofemoral total SRM = −0.87). The lateral tibiofemoral CDI quantification allows for rapid evaluation and is reliable and responsive, with good construct validity. It may be an efficient method to measure lateral tibiofemoral articular cartilage in large clinical and epidemiologic studies.

2038670 Reliability of a Proposed Ultrasonographic Grading Scale for Severity of Primary Knee Osteoarthritis

“…Also, the proposed scale depended only on ultrasonographic features, which did not provide information about the changes that occur in the subchondral bone marrow and that are related to structural and symptomatic osteoarthritis progression. 30 In conclusion, the proposed ultrasonographic grading scale of knee OA was proved to be a reliable and a comparable tool to K&L scale of CR. Good agreement was found between the proposed US grading scale and K&L grading scale.…”

Role of Magnetic Resonance Imaging in Classifying Individuals Who Will Develop Accelerated Radiographic Knee Osteoarthritis

“…To measure tibiofemoral cartilage we used the validated cartilage damage index (CDI) . One reader (J.E.D.)…”

“…One reader (J.E.D.) manually marked the bone‐cartilage boundary on specific knee slices that are automatically selected based on the presence of predefined informative locations . The reader then measured cartilage thickness at predefined 36 informative locations, which the software automatically located.…”

“…To measure tibiofemoral cartilage we used the validated cartilage damage index (CDI). 20,21 One reader (J.E.D.) manually marked the bone-cartilage boundary on specific knee slices that are automatically selected based on the presence of predefined informative locations.…”

“…manually marked the bone-cartilage boundary on specific knee slices that are automatically selected based on the presence of predefined informative locations. 20,21 The reader then measured cartilage thickness at predefined 36 informative locations, which the software automatically located. The software then computed the CDI for the medial femur, lateral femur, medial tibia, and lateral tibia by summing the products of cartilage thickness, cartilage length (anterior-posterior), and voxel size from nine informative locations in each region.…”