Development of a randomized 3D cell model for Monte Carlo microdosimetry simulations

Douglass, Michael; Bezak, Eva; Penfold, Scott

doi:10.1118/1.4719963

Cited by 34 publications

(29 citation statements)

References 15 publications

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“…Here the combined impacts of low dosages, small cell sizes, and relatively short experiment durations create a scenario where the interactions between radiation and cells need to be considered stochastically, rather than in terms of a dose absorbed (as has been widely used to date). Monte-Carlo based particle track simulation packages have seen wide use in simulating the impact of radiation upon cells in radiotherapy [24, 25] and are easily applicable to cellular dosimetry [26, 27]. Going further, Monte Carlo codes can simulate both direct and reactive oxygen species induced damage caused by radiation sources, both through explicit simulation [28] and analytical modeling of the chemical processes induced by radiation [29].…”

Section: Introductionmentioning

confidence: 99%

Simulating the Impact of the Natural Radiation Background on Bacterial Systems: Implications for Very Low Radiation Biological Experiments

Lampe¹,

Biron²,

Brown³

et al. 2016

PLoS ONE

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At very low radiation dose rates, the effects of energy depositions in cells by ionizing radiation is best understood stochastically, as ionizing particles deposit energy along tracks separated by distances often much larger than the size of cells. We present a thorough analysis of the stochastic impact of the natural radiative background on cells, focusing our attention on E. coli grown as part of a long term evolution experiment in both underground and surface laboratories. The chance per day that a particle track interacts with a cell in the surface laboratory was found to be 6 × 10−5 day−1, 100 times less than the expected daily mutation rate for E. coli under our experimental conditions. In order for the chance cells are hit to approach the mutation rate, a gamma background dose rate of 20 μGy hr−1 is predicted to be required.

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Section: Introductionmentioning

confidence: 99%

Simulating the Impact of the Natural Radiation Background on Bacterial Systems: Implications for Very Low Radiation Biological Experiments

Lampe¹,

Biron²,

Brown³

et al. 2016

PLoS ONE

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“…, 200 keV) could induce dramatic emission of photoelectrons that damage biological macromolecules145. Douglass developed a randomized 3D cell model for Monte Carlo microdosimetry simulations in the keV range31. McMahon showed the calculations of biological consequences of energy deposition near irradiated heavy atom NPs; the results of these calculations were consistent with cellular experiments under keV radiation29.…”

mentioning

confidence: 81%

Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements

Xing

Zheng

Ren

et al. 2013

Sci Rep

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The clinical potentials of radiotherapy could not be achieved completely because of the inaccurate positioning and inherent radioresistance of tumours. In this study, a novel active-targeting upconversion theranostic agent (arginine-glycine-aspartic acid-labelled BaYbF5: 2% Er3+ nanocube) was developed for the first time to address these clinical demands. Heavy metal-based nanocubes (~10 nm) are potential theranostic agents with bifunctional features: computed tomography (CT) contrast agents for targeted tumour imaging and irradiation dose enhancers in tumours during radiotherapy. Remarkably, they showed low toxicity and excellent performance in active-targeting CT imaging and CT imaging-guided radiosensitizing therapy, which could greatly concentrate and enlarge the irradiation dose deposition in tumours to enhance therapeutic efficacy and minimize the damage to surrounding tissues.

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“…In the past, simplified spheroid models with different cell and nucleus radii were used to model cells [75]. Recently, some more realistic cell and tumour models were built [76][77][78]. Most of the works published to-date have modelled Xrays, gamma-rays and low energy electrons and have investigated production of SSBs and DSBs in order to evaluate the efficacy of various radiation therapy modalities.…”

Section: Conventional Radiation Therapymentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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Development of a randomized 3D cell model for Monte Carlo microdosimetry simulations

Cited by 34 publications

References 15 publications

Simulating the Impact of the Natural Radiation Background on Bacterial Systems: Implications for Very Low Radiation Biological Experiments

Simulating the Impact of the Natural Radiation Background on Bacterial Systems: Implications for Very Low Radiation Biological Experiments

Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements

Review of Geant4-DNA applications for micro and nanoscale simulations

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