To satisfy the requirements of underground engineering applications, an anti-radon coating was developed by selecting suitable modified polymer emulsions, element materials, pigments, fillers, additives, etc. Experimental results on radon mitigation performance show that for a coating thickness of 2.0 mm, the radon mitigation efficiency reaches 95.1%. In addition, an anti-radon coating has a very low content of toxic substances and excellent water resistance and durability. Using the coating in an engineering application showed that the coating has the advantages of fast drying speed, no peculiar smell and excellent radon mitigation performance, where 2-3 coats produce good radon mitigation in damp and sealed underground engineering environments.