Development of a questionnaire-based insecticide exposure assessment method and comparison with urinary insecticide biomarkers in young Australian children

English, Karin; Li, Yan; Jagals, Paul; Ware, Robert S.; Wang, Xianyu; He, Chang; Mueller, Jochen F.; Sly, Peter D.

doi:10.1016/j.envres.2019.108613

Cited by 11 publications

(11 citation statements)

References 59 publications

(9 reference statements)

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“…The pyrethroid burden depends on dietary habits (fruit and vegetable consumption) and smoking status but also domestic pesticide use, the presence of an animal in the household, and handwashing frequency 4,110,127,130 . Adults are contaminated mostly by dietary ingestion.…”

Section: Resultsmentioning

confidence: 99%

“…The effectiveness of handwashing varies according to the pesticide used 149 . Moreover, a cross‐sectional study of 56 children younger than 2 years in Australia showed that handwashing more than 3 times a day was associated with lower levels of urinary pesticide metabolites ( LE4 ) 130 …”

Section: Resultsmentioning

confidence: 99%

“…149 Moreover, a cross-sectional study of 56 children younger than 2 years in Australia showed that handwashing more than 3 times a day was associated with lower levels of urinary pesticide metabolites (LE). 130 Gloves and long clothing can diminish dermal exposure to pesticides. A crossover experimental study of 36 agricultural workers showed that wearing gloves (either single-use or cotton) reduced the quantity of pesticides found in the handwashing water after the activity that caused exposure.…”

Section: Reducing Pesticide Exposurementioning

confidence: 99%

“…129 The pyrethroid burden depends on dietary habits (fruit and vegetable consumption) and smoking status but also domestic pesticide use, the presence of an animal in the household, and handwashing frequency. 4,110,127,130 Adults are contaminated mostly by dietary ingestion. Nondietary ingestion and cutaneous exposure by dust may represent important sources and could even be the main sources of exposure for young children.…”

Section: Insecticidesmentioning

confidence: 99%

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Domestic Exposure to Chemicals in Household Products, Building Materials, Decoration, and Pesticides: Guidelines for Interventions During the Perinatal Period from the French National College of Midwives

Rousseau¹,

Rouzeau

Bainvel

et al. 2022

J Midwife Womens Health

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Introduction We are exposed to numerous pollutants inside our homes. The perinatal period represents a particular window of vulnerability during which these exposures can have negative health effects over a more or less long term. The objective of this article is to formulate guidelines for health care professionals and intended for parents to reduce exposure to chemical pollutants at home, based on the scientific literature and already existing guidelines. Methods We have followed the methodological procedures set forth by the French authority for health (HAS) to establish guidelines to limit exposure to pollutants in homes. This narrative review of the scientific literature was conducted with two principal objectives: (1) to identify priority substances emitted within homes and that have a reprotoxic potential and (2) to identify measures to limit exposure to these residential pollutants. The guidelines were developed from the data in the literature and from advice already made available by diverse institutions about environmental health during the perinatal period. Results Domestic pollutants are numerous and come from both common (that is, shared, eg, painting, cleaning, and maintenance work) and specific (use of household pesticides) sources. Numerous pollutants are suspected or known to produce developmental toxicity, that is, to be toxic to children during developmental stages. Removing some products from the home, protecting the vulnerable (ie, pregnant women and young children) from exposure, and airing the home are among the preventive measures proposed to limit exposure to these chemical substances. Conclusion Health care professionals can provide advice to parents during the perinatal period to diminish exposure to household pollutants. The lack of interventional studies nonetheless limits the level of evidence for most of these recommendations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Reducing Pesticide Exposurementioning

confidence: 99%

Section: Insecticidesmentioning

confidence: 99%

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Domestic Exposure to Chemicals in Household Products, Building Materials, Decoration, and Pesticides: Guidelines for Interventions During the Perinatal Period from the French National College of Midwives

Rousseau¹,

Rouzeau

Bainvel

et al. 2022

J Midwife Womens Health

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“…β‐Cypermethrin (β‐CYP) is a widely applied type‐II pyrethroid insecticide. Due to its excessive usage, β‐CYP and its metabolites have been detected in environmental matrices (Mehler et al, ; Tang et al, ) and sometimes even accumulate in the bodies of humans or mammals through food chains (English et al, ). Therefore, the toxic effects of β‐CYP have received much attention from the public.…”

Section: Introductionmentioning

confidence: 99%

β‐Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3‐L1 Cell Maturation into Adipocytes

Wang

Jin

et al. 2020

Lipids

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Studies have elucidated that pyrethroids induce adipogenesis. It is also known that macrophages can affect the homeostasis of adipose tissue. However, whether and how the β-cypermethrin (β-CYP)-mediated inhibition of the macrophages affects adipogenesis remain unknown. To explore the effects of β-CYP on adipogenesis through modulating the function of macrophages, 3T3-L1 cells, a preadipocyte cell line, were exposed to culture medium from either RAW 264.7 cells, a macrophage cell line (RM), or β-CYP-treated RAW 264.7 cells (CRM). CRM decreased the inhibitory effects of RM treatment on cell proliferation and adipogenesis, as lipid accumulation, the CEBPA content, and Fasn and Acaca expression in 3T3-L1 cells were higher following CRM treatment than following RM treatment through the higher levels of the demethylated CEBPA promoter in 3T3-L1 cells. However, the medium from β-CYPand Nacetyl-L-cysteine-cotreated RAW 264.7 cells (CNRM) partially restored the inhibitory effects of RAW 264.7 cells on 3T3-L1 cells that had been reduced by CRM, indicating that β-CYP might reduce the cytotoxicity and inhibitory effects of RAW 264.7 cells on the adipogenesis of 3T3-L1 cells through elevating ROS levels in RAW 264.7 cells. Moreover, exposure to β-CYP downregulated the TNF-α secretion in RAW 264.7 cells. In conclusion, these data demonstrated that β-CYP affected the function of RAW 264.7 cells, alleviating their inhibitory effects on adipogenesis and CEBPA demethylation in 3T3-L1 cells. β-CYP might achieve these effects through downregulating the secretion of TNF-α via elevating ROS levels in RAW 264.7 cells. Our experiments provide a new perspective on the obesogenic effect of pyrethroids.

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Elevated accumulation and distinct migration patterns of neonicotinoids compared to traditional insecticides in South China typical orchard

Song,

Li,

Wei

et al. 2024

Emerging Contaminants

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Development of a questionnaire-based insecticide exposure assessment method and comparison with urinary insecticide biomarkers in young Australian children

Cited by 11 publications

References 59 publications

Domestic Exposure to Chemicals in Household Products, Building Materials, Decoration, and Pesticides: Guidelines for Interventions During the Perinatal Period from the French National College of Midwives

Domestic Exposure to Chemicals in Household Products, Building Materials, Decoration, and Pesticides: Guidelines for Interventions During the Perinatal Period from the French National College of Midwives

β‐Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3‐L1 Cell Maturation into Adipocytes

Elevated accumulation and distinct migration patterns of neonicotinoids compared to traditional insecticides in South China typical orchard

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