Development of a quantifiable optical reader for lateral flow immunoassay

Yang, Yongliang; Gu, Yongbin; Ge, Shengxiang; Tang, Zhenyun; Qiu, Xianbo

doi:10.1109/bmei.2015.7401527

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Photodiodes are simple photodetectors that convert light into electrical signals and are widely used in optical test strip readers due to their low cost and ease of use [53]. Photomultiplier tubes (PMTs) are highly sensitive photodetectors that amplify the fluorescence signal using a cascade of dynodes and are capable of detecting very low-intensity light, making them very applicable for highly sensitive fluorescence light occurrences.…”

Section: Light Detectormentioning

confidence: 99%

Emerging Technologies for Fluorescence-Based Optical Test Strip Readers

AKSOY

DULDA

Ertas

2023

EJOSAT

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Fluorescence-based optical test strip readers are used to detect and quantify fluorescent signals from immunoassay test strips in medicine, especially for point-of-care applications. The design of optical systems including light sources and detection systems in these devices is not only indispensable but also the most critical part for specific detection applications. This study aims to provide detailed information about fluorescence-based optical test strip readers, existing and emerging technologies, and their contributions to the design of the device. The most commonly used technologies of light sources and detection systems have been discussed and compared for the ideal design. Arc and Xenon lamps may not be appropriate for portable and low-cost devices as they are larger and more costly when compared to LEDs and laser diodes. Photodiodes and CMOS detectors can be used for the design of low-cost, portable fluorescence-based optical test strip readers as they are cheaper and smaller in size when compared to CCDs and PMTs. Both light source and detector should be chosen according to the application priorities and spectral characteristics of the fluorescent molecule by integrating them with proper optical elements like filters, mirrors, etc. This study contributes to the people who are interested in the design of fluorescence-based optical test strip readers as it serves as a guideline for the optical test strip reader systems.

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Section: Light Detectormentioning

confidence: 99%

Emerging Technologies for Fluorescence-Based Optical Test Strip Readers

AKSOY

DULDA

Ertas

2023

EJOSAT

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“…Concerning detection, there are three types of identified measurements: (i) qualitative, to detect the presence or absence of a marker in a specimen; (ii) quantitative, to determine the amount or concentration of a marker in a specimen; and (iii) semiquantitative, to screen specimens on certain markers in a certain concentration range. Despite the type of measurement, the Optical PoC technology allows extremely parallelized (i.e., multiplexed) and fine-tuned measurements, surpassing on many occasions the precision of conventional analysis [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

A review of Optical Point-of-Care devices to Estimate the Technology Transfer of These Cutting-Edge Technologies

et al. 2022

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Despite the remarkable development related to Point-of-Care devices based on optical technology, their difficulties when used outside of research laboratories are notable. In this sense, it would be interesting to ask ourselves what the degree of transferability of the research work to the market is, for example, by analysing the relation between the scientific work developed and the registered one, through patent. In this work, we provide an overview of the state-of-the-art in the sector of optical Point-of-Care devices, not only in the research area but also regarding their transfer to market. To this end, we explored a methodology for searching articles and patents to obtain an indicator that relates to both. This figure of merit to estimate this transfer is based on classifying the relevant research articles in the area and the patents that have been generated from these ones. To delimit the scope of this study, we researched the results of a large enough number of publications in the period from 2015 to 2020, by using keywords “biosensor”, “optic”, and “device” to obtain the most representative articles from Web of Science and Scopus. Then, we classified them according to a particular classification of the optical PoC devices. Once we had this sampling frame, we defined a patent search strategy to cross-link the article with a registered patent (by surfing Google Patents) and classified them accordingly to the categories described. Finally, we proposed a relative figure called Index of Technology Transference (IoTT), which estimates to what extent our findings in science materialized in published articles are protected by patent.

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Development of a quantifiable optical reader for lateral flow immunoassay

Cited by 2 publications

References 25 publications

Emerging Technologies for Fluorescence-Based Optical Test Strip Readers

Emerging Technologies for Fluorescence-Based Optical Test Strip Readers

A review of Optical Point-of-Care devices to Estimate the Technology Transfer of These Cutting-Edge Technologies

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