Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes

Zhang, Xiangxin; Liu, Yang; Kong, Ming; Ma, Jian; Wei, Yongzhong

doi:10.1186/s12859-021-04456-2

Cited by 5 publications

(4 citation statements)

References 60 publications

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“…This complex recruits the deubiquitinating enzyme UCH37 to the 26S proteasome 40 . In tumors, the 12 prognosis-related genes including ADRM1 might be promising therapeutic targets esophageal adenocarcinoma 41 . RA190, a specific inhibitor of ADRM1, induces apoptosis intrahepatic cholangiocarcinoma cells 42 .…”

Section: Discussionmentioning

confidence: 99%

Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer

Yu,

Wang,

Liu

et al. 2023

Sci Rep

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Adhesion-regulating molecule 1 (ADRM1) has been implicated in tumor development, yet its specific role in bladder cancer (BC) remains undefined. This study aimed to elucidate the function of ADRM1 in BC through a combination of bioinformatics analysis and immunohistochemical analysis (IHC). Utilizing R version 3.6.3 and relevant packages, we analyzed online database data. Validation was conducted through IHC data, approved by the Institutional Ethics Committee (Approval No. K20220830). In both paired and unpaired comparisons, ADRM1 expression was significantly elevated in BC tissues compared to adjacent tissues, as evidenced by the results of TCGA dataset and IHC data. Patients with high ADRM1 expression had statistically worse overall survival than those with low ADRM1 expression in TCGA dataset, GSE32548 dataset, GSE32894 dataset, and IHC data. Functional analysis unveiled enrichment in immune-related pathways, and a robust positive correlation emerged between ADRM1 expression and pivotal immune checkpoints, including CD274, PDCD1, and PDCD1LG2. In tumor microenvironment, samples with the high ADRM1 expression contained statistical higher proportion of CD8 + T cells and Macrophage infiltration. Meanwhile, these high ADRM1-expressing samples displayed elevated tumor mutation burden scores and stemness indices, implying potential benefits from immunotherapy. Patients with low ADRM1 expression were sensitive to cisplatin, docetaxel, vinblastine, mitomycin C, and methotrexate. According to the findings from bioinformatics and IHC analyses, ADRM1 demonstrates prognostic significance for BC patients and holds predictive potential for both immunotherapy and chemotherapy responses. This underscores its role as a biomarker and therapeutic target in BC.

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Section: Discussionmentioning

confidence: 99%

Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer

Yu,

Wang,

Liu

et al. 2023

Sci Rep

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“…A previous similar study also investigated the prognostic factor, immune cell infiltration, and immune-related pathways in EAC [ 82 ]. Zhang et al found 12 IRGs (ADRM1, CXCL1, SEMG1, CCL26, CCL24, AREG, IL23A, UCN2, FGFR4, IL17RB, TNFRSF11A and TNFRSF21) in EAC.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, CCL26, CCL24, AREG, IL23A, TNFRSF11A, and TNFRSF21 were independent risk factors in EAC. Immune cell infiltration analysis showed that M0 was positively correlated with the high-risk group, while M1 and plasma cells were positively correlated with the low-risk group [ 82 ], but they did not explore the immune-related pathways in EAC. In the present study, we constructed an IRGS based on multivariate Cox regression analysis, and we found UNC93B1 and HSPA14 are the independent risk factors in EAC.…”

Section: Discussionmentioning

confidence: 99%

An Immune-Related Gene Signature for Predicting Survival and Immunotherapy Efficacy in Esophageal Adenocarcinoma

Yang

Cao

2023

Med Sci Monit

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Background Immune checkpoint inhibitor (ICI) therapy has attracted wide attention in the treatment of malignant tumors. This study was designed to build a prognostic model based on immune-related genes for esophageal adenocarcinoma (EAC). Material/Methods The expression of immune-related differentially-expressed genes (IRDEGs) between EAC and normal samples from The Cancer Genome Atlas database was analyzed. Univariate and multivariate Cox regressions were used to identify the prognostic IRDEGs and construct an immune-related gene signature (IRGS) to predict the overall survival (OS) of EAC patients. Then, the molecular mechanisms and immune characteristics were comprehensively analyzed. Results A total of 111 IRDEGs were obtained from the weighted gene co-expression network analysis. Univariate Cox regression analysis showed that 12 IRDEGs ( P <0.05 for all) were linked with OS in the EAC patients. Four genes were used to construct the IRGS based on the multivariate Cox regression analysis. Patients in the high-risk group showed worse OS than those in the low-risk group ( P <0.001). A high-risk score was related to DNA replication relevant pathways, an increase in mutation rate, and an increase in activated mast cell infiltration. Patients with high-risk scores had lower tumor immune dysfunction and exclusion scores ( P <0.001). Conclusions IRDEGs may be involved in the progression of EAC. The high-risk group is more suitable for immunotherapy, which may provide a reference value for the treatment of clinical EAC patients. Therefore, it is possible to identify the patients who are better suited for ICI therapy.

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“…TNFRSF21 is the member of the TNF receptor superfamily. Studies suggested that TNFRSF21 might serve as a prognostic marker for esophageal squamous cell carcinoma ( Qiu et al, 2021 ) and esophagus adenocarcinoma ( Zhang et al, 2021 ). Furthermore, it should be mentioned that the impact and mechanism of these seven NRGs in HCC have not been reported yet, and future experiments are needed to provide more evidence.…”

Section: Discussionmentioning

confidence: 99%

Establishment of a Necroptosis-Related Prognostic Signature to Reveal Immune Infiltration and Predict Drug Sensitivity in Hepatocellular Carcinoma

et al. 2022

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Background: Hepatocellular carcinoma (HCC) is a common type of primary liver cancer and has a poor prognosis. In recent times, necroptosis has been reported to be involved in the progression of multiple cancers. However, the role of necroptosis in HCC prognosis remains elusive.Methods: The RNA-seq data and clinical information of HCC patients were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Differentially expressed genes (DEGs) and prognosis-related genes were explored, and the nonnegative matrix factorization (NMF) clustering algorithm was applied to divide HCC patients into different subtypes. Based on the prognosis-related DEGs, univariate Cox and LASSO Cox regression analyses were used to construct a necroptosis-related prognostic model. The relationship between the prognostic model and immune cell infiltration, tumor mutational burden (TMB), and drug response were explored.Results: In this study, 13 prognosis-related DEGs were confirmed from 18 DEGs and 24 prognostic-related genes. Based on the prognosis-related DEGs, patients in the TCGA cohort were clustered into three subtypes by the NMF algorithm, and patients in C3 had better survival. A necroptosis-related prognostic model was established according to LASSO analysis, and HCC patients in TCGA and ICGC were divided into high- and low-risk groups. Kaplan–Meier (K–M) survival analysis revealed that patients in the high-risk group had a shorter survival time compared to those in the low-risk group. Using univariate and multivariate Cox analyses, the prognostic model was identified as an independent prognostic factor and had better survival predictive ability in HCC patients compared with other clinical biomarkers. Furthermore, the results revealed that the high-risk patients had higher stromal, immune, and ESTIMATE scores; higher TP53 mutation rate; higher TMB; and lower tumor purities compared to those in the low-risk group. In addition, there were significant differences in predicting the drug response between the high- and low-risk groups. The protein and mRNA levels of these prognostic genes were upregulated in HCC tissues compared to normal liver tissues.Conclusion: We established a necroptosis-related prognostic signature that may provide guidance for individualized drug therapy in HCC patients; however, further experimentation is needed to validate our results.

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Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes

Cited by 5 publications

References 60 publications

Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer

Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer

An Immune-Related Gene Signature for Predicting Survival and Immunotherapy Efficacy in Esophageal Adenocarcinoma

Establishment of a Necroptosis-Related Prognostic Signature to Reveal Immune Infiltration and Predict Drug Sensitivity in Hepatocellular Carcinoma

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