Development of a preliminary essential medicines list for Canada

Taglione, Michael Sergio; Ahmad, Haroon; Slater, Morgan; Aliarzadeh, Babak; Glazier, Richard H.; Laupacis, Andreas; Persaud, Nav

doi:10.9778/cmajo.20160122

Cited by 19 publications

(29 citation statements)

References 9 publications

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“…We found that nearly half (44%) of all prescriptions filled at re tail pharmacies in Canada in 2015 were for 117 drugs on a model essential medicines list for Canada (the CLEAN Meds list 29 ). An additional 33% of prescriptions filled were for drugs from the same chemical subclasses as 1 or more medicine from the essential medicines list.…”

Section: Discussionmentioning

confidence: 99%

“…29 Our analysis focused on 117 of the CLEAN Meds drugs (hereafter "the essential medicines") that are available and sold as prescriptiononly medicines in Canada (Appendix 1, available at www.cmaj.ca/lookup/suppl/ doi:10.1503/cmaj.161082//DC1). Although predominantly target ing primary health care needs, some medicines on the list are often prescribed by specialists (e.g., treatments for hepatitis and HIV infection, and a biologic drug for inflammatory conditions).…”

Section: Selection and Classification Of Medicinesmentioning

confidence: 99%

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Estimated effects of adding universal public coverage of an essential medicines list to existing public drug plans in Canada

Morgan

Persaud

2017

CMAJ

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Section: Discussionmentioning

confidence: 99%

Section: Selection and Classification Of Medicinesmentioning

confidence: 99%

Estimated effects of adding universal public coverage of an essential medicines list to existing public drug plans in Canada

Morgan

Persaud

2017

CMAJ

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“…In its active form, lamivudine competes for incorporation into viral DNA and act as chain terminator in viral DNA synthesis [2]. According to WHO, it is one of the essential medicines in a basic health system [3].…”

Section: Introductionmentioning

confidence: 99%

Histomorphological effect of Lamivudine on the Cerebellum of Wistar rats

Peter¹,

Udoh²,

Ekanem³

2017

Histol Cytol Embryol

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Lamivudine is an anti-retroviral drug used for the treatment of HIV and hepatitis B. It is one of the essential medicines needed in a basic health system. This study was carried out to investigate the detrimental effect of lamivudine on the cerebellum based on the adverse effects of gait disorders manifested by patients using lamivudine. Twenty male Wistar rats divided into two groups of ten rats each were used for the study. Control group A was administered with 1ml of distilled water, while treatment group B was treated with 4.28mg/kg of lamivudine daily for 30 days. On the 30 th day, the rats were euthanized and each cerebellum was harvested immediately. The cerebella were put through routine tissue processing for H/E staining and GFAP immunohistochemical method. The resulting specimens were mounted with DPX and viewed under the light microscope at ×400. Photomicrographs showed shrunken Purkinje cells and distorted granular layer in the cerebellum of group B rats while those of group A rats were healthy. Also, image J counting showed reduced number of cells in the lamivudine group. This correlated with the higher staining intensity for GFAP in the granular layer of group B rats suggesting cellular inflammation and damage. More research is needed to ascertain the molecular mechanism of these distortions.

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“…As previously described, 3 we adapted the 2013 WHO essential medicines list 16 to create a preliminary essential medicines list for adults in Canada. The purpose of this process was to identify the medicines on the WHO list that are applicable to Canada.…”

Section: Adaptation Of World Health Organization Essential Medicines mentioning

confidence: 99%

“…7,8,12,14,15 Our aim was to develop a list of essential medicines for children in Canada based on the WHO Model List of Essential Medicines for Children 16 and on the adult essential medicines list we previously created. 3 …”

mentioning

confidence: 99%