Development of a Pre‐assembled Through‐Bond Energy Transfer (TBET) Fluorescent Probe for Ratiometric Sensing of Anticancer Platinum(ll) Complexes

Abstract

Fluorescence microscopy has emerged as an attractive technique to probe the intracellular processing of Pt-based anticancer compounds. Herein, we reported the first through-bond energy transfer (TBET) fluorescent probe NPR1 designed for sensitive detection and quantitation of Pt II complexes. The novel TBET probe was successfully applied for ratiometric fluorescence imaging of anticancer Pt II com-plexes such as cisplatin and JM118 in cells. Capitalizing on the ability of the probe to discriminate between Pt II complexes and their Pt IV derivatives, the probe was further applied to study the activation of Pt IV prodrug complexes that are known to release active Pt II species after intracellular reduction.[a] Dr.

Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective PlatinumIV Prodrug Against Triple Negative Breast Cancer

“…However, treatment with these platinum‐based drugs quickly develops chemoresistance that ultimately leads to therapeutic failure [6] . On the other hand, Pt IV complexes have shown great potential in recent years [7a,b] . Pt IV scaffold with extra two axial ligands provides a synthetic advantage to fine‐tune the stability, biological activity and oral availability [8] .…”

Rational Design and Biological Application of Hybrid Fluorophores

“…Furthermore, the fluorophores involved in the hybridization were not limited to the four classic fluorophores mentioned in this review. There are many other models formed by the hybridization of other fluorophore, such as perylene, [140] benzothiophene, [145] naphthalimide, [31,148,149] triphenylamine [44,150] and carbopyronine, [146] which also have [91] Reproduced from ref. [91] Copyright (2022), with permission from American Chemical Society.…”

Fluorescent and chromogenic organic probes to detect group 10 metal ions: design strategies and sensing applications

“…Platinum (Pt) is a precious metal that is widely employed in various catalytic conversions, gas adsorbing materials, fuel cells, therapeutic agents, jewels, dental crowns, etc . 175,176 In particular as anticancer agents, Pt( ii )-based compounds have exhibited remarkable optical, biological and catalytic properties. 177 Catalysts with several activities, such as carbophilic activation, oxidation, and hydration, can be developed from Pt( ii ) complexes.…”