Development of a Polymeric Patch Impregnated with Naproxen as a Model of Transdermal Sustained Release System

Drug loading of polymer implants by supercritical CO 2 assisted impregnation: A review

“…ScCO 2 enables the swelling of the polymer thus the mass transfer of the drug into the matrix is increased. The process is even more facilitated when the solvent enhances the swelling of the polymer [100,[117][118][119]. The protein β-galactosidase was successfully impregnated into polystyrene even if its solubility in dense CO 2 is low [120].…”

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

“…Further, the resultant solution is supplied to a polymer, which facilitates the impregnation of drug in the swollen polymer. [ 99 ] Eventually, the organic solvent traces can be removed post-fabrication, which results in unaltered surface properties of the particles. [ 17 ]…”

Supercritical CO2 for the Reactive Precipitation of Calcium Carbonate: Uses and Applications to Industrial Processing

“…In this application the possibility to homogeneously disperse the active compound in the matrix, the ease of diffusion of the drug into the bulk of the material and the fact that no organic solvents are used is particularly relevant. In the work of Argemi et al [43], transdermal patches were impregnated with naproxen. The membranes prepared have shown a sustainable drug release up to 24 h. The preparation of wound dressings impregnated with two natural bioactive compounds is another example of a drug delivery device prepared using supercritical solvent impregnation reported in the literature [44].…”