Development of a polyacrylamide/chitosan composite hydrogel conduit containing synergistic cues of elasticity and topographies for promoting peripheral nerve regeneration

Liu, Fang; Xu, Jiawei; Liu, Anning; Wu, Linliang; Wang, Dongzhi; Han, Qi; Zheng, Tiantian; Wang, Feiran; Kong, Yan; Li, Guicai; Gu, Shaohua; Yang, Yumin

doi:10.1039/d2bm00327a

Cited by 10 publications

(4 citation statements)

References 71 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitosan and graphene oxide were combined to generate a graft that improves the characteristics of chitosan NGCs 36 . A composite NGCs made of polyacrylamide and chitosan that was customized with mechanical and topographical guidance cues was used to correct a sciatic nerve deficit that measured 15 mm in rabbits 37 . Intriguingly, wet‐weight ratio, electrophysiological, and neuronal histomorphometry tests also revealed that the polyacrylamide/chitosan NGCs using 8.4 kPa and a surface depression with a 30 m range enhanced the regeneration of nerves with homologous nerve grafting 38 .…”

Section: Supportive Biomaterials For Solid Neuronal Glial Cellsmentioning

confidence: 99%

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Kumar,

Malviya,

Sundram

2024

MedComm – Biomaterials and Applications

View full text Add to dashboard Cite

The management of peripheral nerve injuries is an important concern due to the their incidence of nerve lesions and inappropriate regeneration that follows severe injuries, which ultimately reduces the lives of patients with this condition. Different strategies have been investigated to repair severe nerve injuries with the improvement of motor and sensory regeneration. Although autograft remains the gold standard technique, an emerging number of research articles concerning nerve conduit use have been reported in the last few years. Nerve conduits aim to overcome autograft disadvantages, but they satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural‐based biomaterials have great potential to be used to produce nerve guides. Although they have many characteristics with synthetic biomaterials, natural‐based biomaterials are preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review highlights the recent progress in the development of natural‐based biomaterials and their derivatives for the management of peripheral nerve injuries.

show abstract

Section: Supportive Biomaterials For Solid Neuronal Glial Cellsmentioning

confidence: 99%

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Kumar,

Malviya,

Sundram

2024

MedComm – Biomaterials and Applications

View full text Add to dashboard Cite

show abstract

“…Liu et al. designed a hydrogel conduit with a synergistic effect of morphology and elasticity [ 134 ]. The DRG neurite showed good directional growth ability in this synergistic hydrogel injury, and in vivo experimental results showed that the marker protein of axon extension was increased.…”

Section: Hydrogels Combined With Stem Cells For Peripheral Nerve Injurymentioning

confidence: 99%

Engineered hydrogels for peripheral nerve repair

Yao

Zhang

Xiao

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

“…They provide a supportive three-dimensional network structure and regulate the release of bioactive molecules, such as nerve growth factors, to promote nerve regeneration and improve the microenvironment at the injury site [ 118 , 119 ]. The porous structure of the hydrogels facilitates cell invasion and guided growth, enabling nerve cells to reconnect within the injury site [ 2 , 120 , 121 ]. The adhesive properties of the hydrogels promote cell attachment and growth, accelerating the process of nerve regeneration [ 122 , 123 ].…”

Section: Techniques Of Tissue Engineering For Pni Repairmentioning

confidence: 99%

Prospects of Using Chitosan-Based Biopolymers in the Treatment of Peripheral Nerve Injuries

Zhang,

An,

Zhang

et al. 2023

IJMS

View full text Add to dashboard Cite

Peripheral nerve injuries are common neurological disorders, and the available treatment options, such as conservative management and surgical repair, often yield limited results. However, there is growing interest in the potential of using chitosan-based biopolymers as a novel therapeutic approach to treating these injuries. Chitosan-based biopolymers possess unique characteristics, including biocompatibility, biodegradability, and the ability to stimulate cell proliferation, making them highly suitable for repairing nerve defects and promoting nerve regeneration and functional recovery. Furthermore, these biopolymers can be utilized in drug delivery systems to control the release of therapeutic agents and facilitate the growth of nerve cells. This comprehensive review focuses on the latest advancements in utilizing chitosan-based biopolymers for peripheral nerve regeneration. By harnessing the potential of chitosan-based biopolymers, we can pave the way for innovative treatment strategies that significantly improve the outcomes of peripheral nerve injury repair, offering renewed hope and better prospects for patients in need.

show abstract

Development of a polyacrylamide/chitosan composite hydrogel conduit containing synergistic cues of elasticity and topographies for promoting peripheral nerve regeneration

Abstract: The substrate elasticity and topographical guidance are crucial factors for regulating tissue regeneration. However, the synergistic effects of both cues on peripheral nerve regeneration are still unclear. Herein, the polyacrylamide/chitosan...

Cited by 10 publications

References 71 publications

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Engineered hydrogels for peripheral nerve repair

Prospects of Using Chitosan-Based Biopolymers in the Treatment of Peripheral Nerve Injuries

Contact Info

Product

Resources

About