Development of a phytotherapeutic prototype based on triterpenes encapsulated in nanocarriers for the treatment of obesity and T2DM.

Escobar, Elizam; Fernández, Maritza; Betancur, L; Muñoz, Daniela; Acı́n, Sergio; Orozco, Jahir; Balcazar, Norman

doi:10.1055/s-0041-1736790

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“…A good example that summarizes everything that this review tries to expose is reflected in the work of Escobar et al [ 148 ] in which the use, in diets of prediabetic obese rats, of nanotransporters, constructed with a polymer of polylactic acid-coglycolic acid and in which a set of natural triterpenic compounds are encapsulated, achieved, in addition to a greater gastrointestinal release of these triterpenes, a high efficacy in the reduction of obesity concomitant with diabetes together with significant changes in the main metabolic markers related to DMT2 (diabetes mellitus type 2). All this allows us to recognize that the inclusion of phytochemicals in the diet causes a significant increase in the health state of the animals.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Nutraceutical Role of Polyphenols and Triterpenes Present in the Extracts of Fruits and Leaves of Olea europaea as Antioxidants, Anti-Infectives and Anticancer Agents on Healthy Growth

et al. 2022

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There is currently a worldwide consensus and recognition of the undoubted health benefits of the so-called Mediterranean diet, with its intake being associated with a lower risk of mortality. The most important characteristics of this type of diet are based on the consumption of significant amounts of fruit, vegetables, legumes, and nuts, which provide, in addition to some active ingredients, fiber and a proportion of vegetable protein, together with extra virgin olive oil (EVOO) as the main sources of vegetable fat. Fish and meat from poultry and other small farm animals are the main sources of protein. One of the main components, as already mentioned, is EVOO, which is rich in monounsaturated fatty acids and to a lesser extent in polyunsaturated fatty acids. The intake of this type of nutrient also provides an important set of phytochemicals whose health potential is widely spread and agreed upon. These phytochemicals include significant amounts of anthocyanins, stilbenes, flavonoids, phenolic acids, and terpenes of varying complexities. Therefore, the inclusion in the diet of this type of molecules, with a proven healthy effect, provides an unquestionable preventive and/or curative activity on an important group of pathologies related to cardiovascular, infectious, and cancerous diseases, as well as those related to the metabolic syndrome. The aim of this review is therefore to shed light on the nutraceutical role of two of the main phytochemicals present in Olea europaea fruit and leaf extracts, polyphenols, and triterpenes, on healthy animal growth. Their immunomodulatory, anti-infective, antioxidant, anti-aging, and anti-carcinogenic capabilities show them to be potential nutraceuticals, providing healthy growth.

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Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%