2007
DOI: 10.1208/pt0801026
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Development of a peptide-containing chewing gum as a sustained release antiplaque antimicrobial delivery system

Abstract: The objective of this study was to characterize the stability of KSL-W, an antimicrobial decapeptide shown to inhibit the growth of oral bacterial strains associated with caries development and plaque formation, and its potential as an antiplaque agent in a chewing gum formulation. KSL-W formulations with or without the commercial antibacterial agent cetylpyridinium chloride (CPC) were prepared. The release of KSL-W from the gums was assessed in vitro using a chewing gum apparatus and in vivo by a chew-out met… Show more

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Cited by 44 publications
(33 citation statements)
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“…In vitro toxicity studies showed that KSL did not induce cell death or compromise the membrane integrity of human gingival fibroblasts [8]. In addition, KSL and its analogue KSL-W possess the stability, adsorption and release characteristics necessary for local delivery to the oral cavity in a chewing gum formulation, thereby serving as a practically useful antiplaque agent [19][20][21]. As mentioned above, previous studies demonstrated that KSL inhibited selected oral and non-oral pathogens as well as oral biofilms [4,18].…”
Section: Introductionmentioning
confidence: 94%
“…In vitro toxicity studies showed that KSL did not induce cell death or compromise the membrane integrity of human gingival fibroblasts [8]. In addition, KSL and its analogue KSL-W possess the stability, adsorption and release characteristics necessary for local delivery to the oral cavity in a chewing gum formulation, thereby serving as a practically useful antiplaque agent [19][20][21]. As mentioned above, previous studies demonstrated that KSL inhibited selected oral and non-oral pathogens as well as oral biofilms [4,18].…”
Section: Introductionmentioning
confidence: 94%
“…Chewing gums are being tested for the delivery of substances such as KSL-W [140], an antimicrobial decapeptide. Likewise, available on the market are chewing gums and lozenges with salivaricin-producing strains of the probiotic strain S. salivarius K12 (commercialized by BLIS Technologies Ltd. [www.blis.co.uk]).…”
Section: Bacteriocins and Probiotics In The Oral Cavitymentioning
confidence: 99%
“…(8)(9)(10). Several studies (12,(15)(16)(17)(18)(19)(20)(21) have been carried out using the Ph. Eur.…”
Section: Ph Eurmentioning
confidence: 99%