Development of a Penicillin Allergy Electronic Decision Support Pathway for Pediatric Inpatient Admissions

Lecerf, Kelsey; Chaparro, Juan D.; Hehmeyer, Jessica; Hussain, Cory; Macias, Charlie; Vegh, Maria; Watson, Joshua R.; Stukus, David R.

doi:10.1016/j.jaci.2019.12.611

Cited by 2 publications

(2 citation statements)

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“…(Harper and Sanchez , Leis, Palmay et al , Lnumerables and Fischer-Cartlidge , Adkinson, Thompson et al 1971, Egger, Smith et al 1997, Rimawi, Griffith, Justo et al 2020, Lo, Lacaria et al 2020 11 by doctors (34%), (Adkinson, Thompson et al 1971, Wood and Wisniewski 1994 and one by nurses (3%). (Lecerf, Chaparro et al 2020)…”

Section: Primary Outcomes: Proportion Of Patients Successfully De-lab...mentioning

confidence: 99%

The effectiveness of interventions that support penicillin allergy assessment and delabeling of adult and pediatric patients by nonallergy specialists: a systematic review and meta-analysis

Powell¹,

Stephens²,

Kohl³

et al. 2023

International Journal of Infectious Diseases

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Section: Primary Outcomes: Proportion Of Patients Successfully De-lab...mentioning

confidence: 99%

The effectiveness of interventions that support penicillin allergy assessment and delabeling of adult and pediatric patients by nonallergy specialists: a systematic review and meta-analysis

Powell¹,

Stephens²,

Kohl³

et al. 2023

International Journal of Infectious Diseases

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“…Delabelling was reported in 14/37 studies. 13–16 , 18 , 23 , 25 , 27 , 28 , 30 , 43–46 Studies had different definitions of ‘delabelling’, and outcomes that were expressed as proportions had different denominators. Studies were divided into three groups based on outcome measurement.…”

Section: Resultsmentioning

confidence: 99%

Health outcomes of penicillin allergy testing in children: a systematic review

Kwok

Heard

May

et al. 2023

Journal of Antimicrobial Chemotherapy

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Background Penicillin allergy labels are commonly acquired in childhood and lead to avoidance of first-line penicillin antibiotics. Understanding the health outcomes of penicillin allergy testing (PAT) can strengthen its place in antimicrobial stewardship efforts. Objectives To identify and summarize the health outcomes of PAT in children. Methods Embase, MEDLINE, Web of Science, Cochrane Library, SCOPUS and CINAHL were searched from inception to 11 Oct 2021 (Embase and MEDLINE updated April 2022). Studies that utilized in vivo PAT in children (≤18 years old) and reported outcomes relevant to the study objectives were included. Results Thirty-seven studies were included in the review, with a total of 8411 participants. The most commonly reported outcomes were delabelling, subsequent penicillin courses, and tolerability to penicillin courses. Ten studies had patient-reported tolerability to subsequent penicillin use, with a median 93.6% (IQR 90.3%–97.8%) of children tolerating a subsequent course of penicillins. In eight studies, a median 97.3% (IQR 96.4%–99.0%) of children were reported as ‘delabelled’ after a negative PAT without further definition. Three separate studies verified delabelling by checking electronic or primary care medical records, where 48.0%–68.3% children were delabelled. No studies reported on outcomes relating to disease burden such as antibiotic resistance, mortality, infection rates or cure rates. Conclusions Safety and efficacy of PAT and subsequent penicillin use was the focus of existing literature. Further research is required to determine the long-term impact of delabelling penicillin allergies on disease burden.

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Development of a Penicillin Allergy Electronic Decision Support Pathway for Pediatric Inpatient Admissions

Cited by 2 publications

References 0 publications

The effectiveness of interventions that support penicillin allergy assessment and delabeling of adult and pediatric patients by nonallergy specialists: a systematic review and meta-analysis

The effectiveness of interventions that support penicillin allergy assessment and delabeling of adult and pediatric patients by nonallergy specialists: a systematic review and meta-analysis

Health outcomes of penicillin allergy testing in children: a systematic review

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