Development of a numerical multi-layer model of skin subjected to pulsed laser irradiation to optimise thermal stimulation in photorejuvenation procedure

Muddassir, Muhammad; Limbert, Georges; Navarro-Alarcon, David

doi:10.1016/j.cmpb.2022.106653

Cited by 5 publications

(4 citation statements)

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“…The volumetric heat source Q l due to laser-skin photothermal interaction in (1) is defined as [2], [35]:…”

Section: B Modelling Laser Light Distribution As a Control Inputmentioning

confidence: 99%

“…Advancements in automated photorejuvenation treatment. From left to right, the conventional treatment was automated and robotised to improve the procedural efficiency [23], followed by the development of a simulation framework to study the thermal distribution in tissue, which can incorporate various biological, physical, and optical parameters of a tissue [35]. Quantification and control of the dose in photorejuvenation are presented here.…”

Section: B Modelling Laser Light Distribution As a Control Inputmentioning

confidence: 99%

“…The spatio-temporal model of the thermal response in (1) can be approximated with a state-space model after spatial discretisation (as done, e.g., in Muddassir et al [35]). This way, the system takes the following vector form:…”

Section: State-space Formulation Of Photo-thermal Interactionmentioning

confidence: 99%

“…3) Design and development of a robotic platform for testing the performance of the thermal dose controller with a tissue phantom. 4) Evaluation of the performance of the proposed controller on an in-silico and gelatin-based tissue phantom; insilico simulations are underpinned by a biophysicsbased constitutive model of laser-skin photo-thermal interactions (see [35]). To the best of the authors' knowledge, the proposed dose unit and thermal controller for photorejuvenation have never been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Model Predictive Thermal Dose Control of a Robotic Laser System to Automate Skin Photorejuvenation

Muddassir

Limbert

Zhang

et al. 2023

IEEE/ASME Trans. Mechatron.

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In this paper, we present a new method to control the thermal stimulation of skin during a photorejuvenation procedure. The proposed method can precisely administer the thermal dose while controlling the tissue's temperature under a safe limit. For that, a model-based treatment controller is developed and evaluated on a three-dimensional biophysicsbased numerical model of skin; A hardware implementation is experimentally tested on a gelatin-based phantom tissue subjected to pulsed laser irradiation. A key component of our method is the use of a new thermal dose metric that enables quantifying and controlling the skin photo-rejuvenation process; This metric represents a suitable alternative to the lack of consensus on the metrics used by the photodermatology community. The reported experiments demonstrate that the developed controller endowed with the proposed dose unit can automatically deliver a prescribed laser irradiation and thermal dose over the tissue surface. The significance of our result is that it provides a control-theoretic framework to automate skin photorejuvenation treatments with thermal-guided robots. This approach has the potential to introduce standards in the automation of these types of photo-treatments.

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“…The volumetric heat source Q l due to laser-skin photothermal interaction in (1) is defined as [2], [35]:…”

Section: B Modelling Laser Light Distribution As a Control Inputmentioning

confidence: 99%

Section: B Modelling Laser Light Distribution As a Control Inputmentioning

confidence: 99%

Section: State-space Formulation Of Photo-thermal Interactionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations