Development of a novel salivary gland cancer lymph node staging system

Abstract

Quantitative LN burden is an important determinant of survival in patients with SGC. Use of this variable may improve SGC staging. Cancer 2018. © 2018 American Cancer Society.

The impact of nodal status in major salivary gland carcinoma: A multicenter experience and proposal of a novel N-classification

“…Hong et al, in a cohort of 87 patients with high-grade salivary gland cancer, found that ENE independently affected only DFS. [15] Aro et al [17] and Hsieh et al [37] demonstrated that ENE did not have any impact on survival. It is worth mentioning, however, that a recent report did identify ENE as one of the most important prognostic predictors [18].…”

“…Finally, the prognostic relevance of nodal dimensions and extranodal extension (ENE) are probably the most important nodal predictors in upper aerodigestive tract SCC, yet their significance in MSG carcinoma is less clear [9,[15][16][17][18]. In MSG carcinoma, the nodal disease burden, defined by nodal ratio (NR) and/or number of lymph-nodes involved, may have a more significant prognostic relevance [14][15][16][17][18].…”

Preoperative evaluation and treatment consideration of parotid gland tumors

“…38 We suggest ND for all those who have a cytology class of IV or V, or clinical signs of malignancy, although in some cases, for example, with ACC, 39 Each metastatic lymph node on the neck up to four confers a 34% increased risk of salivary gland cancer mortality. 40 Still, the current tumor staging systems do not account for the absolute number of metastatic lymph nodes in salivary gland cancer, which might influence adjuvant treatment recommendations. Adjuvant RT is commonly recommended in high-grade malignancies, and postoperative RT/CRT was given in this series for 7 (44%) patients who had metastatic disease and/or a high-grade tumor.…”

“…Each metastatic lymph node on the neck up to four confers a 34% increased risk of salivary gland cancer mortality 40 . Still, the current tumor staging systems do not account for the absolute number of metastatic lymph nodes in salivary gland cancer, which might influence adjuvant treatment recommendations.…”

Diagnostic value of fluorine‑18 fluorodeoxyglucose positron emission tomography/computed tomography in sublingual and submandibular salivary gland tumors

“…Salivary gland tumors are associated with a high mortality rate, which may be attributed by the fact that they are more prone to metastasize to distant sites compared with other head and neck cancers (2). The rate of metastasis is 20-28% for submandibular and >90% for sublingual gland tumors (2)(3)(4). It has been reported that regional and distant metastasis of salivary gland cancer are important prognostic indicators for survival post-treatment (5).…”