Development of a novel rodent model for dog heartworm microfilaremia using the severe-combined immunodeficiency mouse
Mihoko Mizuseki,
Nao Ikeda,
Takahiro Shirozu
et al.
Abstract:Dirofilaria immitis is a mosquito-borne parasitic nematode that causes fatal heartworm disease in canids. The fine microfilariae are essential for research, including drug screening and mosquito-parasite interactions. However, no reliable methods for maintaining fine microfilaria long-term are currently available. Therefore, we used severe combined immunodeficiency (SCID) mice to develop a reliable method for maintaining D. immitis microfilaria. SCID mice were injected intravenously with microfilariae isolated… Show more
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