Development of a novel phantom using polyethylene glycol for the visualization of restricted diffusion in diffusion kurtosis imaging and apparent diffusion coefficient subtraction method

Khasawneh, Abdullah; Kuroda, Masahiro; Yoshimura, Yuichiro; Sugianto, Irfan; Bamgbose, Babatunde O.; Hamada, Kentaro; Barham, Majd; Tekiki, Nouha; Konishi, Katsuaki; Sugimoto, Kohei; Ishizaka, Hinata; Kurozumi, Akira; Matsushita, Toshi; Ohno, Seiichiro; Kanazawa, Susumu; Asaumi, Junichi

doi:10.3892/br.2020.1359

Cited by 4 publications

(12 citation statements)

References 26 publications

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“…In terms of phantoms for RD, the PEG phantom has been reported to mimic the conditions of RD in vitro , indicating that it can be utilized as the standard phantom for RD imaging [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…The PEG phantom [ 16 ], which was used as the newly developed RD phantom [ 13 ], consisted of the following three components: i) PEG (cat. no.…”

Section: Methodsmentioning

confidence: 99%

“…This tool was then used to prepare a mean kurtosis (MK) image, which is a mean of kurtosis values calculated for each spatial direction. To create MK images, the MK value for each pixel was calculated using Eq 4 [ 13 ], according to the theoretical description of ‘DKI protocols’ ( https://medicine.musc.edu/departments/centers/cbi/dki/protocols ), where S is the signal intensity of pixels in the DW image and S 0 is the signal intensity when the b-value is 0 sec/mm 2 . The b-values used were 0, 500 and 1,000 sec/mm 2 for both DKI-1 and DKI-2 and only 0 sec/mm 2 for DKI-3.…”

Section: Methodsmentioning

confidence: 99%

Section: Creation Of Dk Imagesmentioning

confidence: 99%

“…A fast imaging sequence was developed for the clinical application of ASM [ 12 ]. In addition, special MR phantom using polyethylene glycol (PEG) has been developed and proved to be the standard for RD imaging, such as ASM and DK imaging [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of calculation processes of apparent diffusion coefficient subtraction method (ASM) imaging

Barham

Kuroda²,

Yoshimura³

et al. 2023

PLoS ONE

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A number of restricted diffusion (RD) imaging techniques, such as diffusion kurtosis (DK) imaging and Q space imaging, have been developed and proven to be useful for the diagnosis of diseases, including cerebral gliomas and cerebrovascular infarction. In particular, apparent diffusion coefficient (ADC) subtraction method (ASM) imaging has become available recently as a novel RD imaging technique. ASM is based on the difference between the ADC values in an image pair of two ADC maps, ADC basic (ADCb) and ADC modify (ADCm), which are created from diffusion-weighted images taken using short and long effective diffusion times, respectively. The present study aimed to assess the potential of different types of ASM imaging by comparing them with DK imaging which is the gold-standard RD imaging technique. In the present basic study using both polyethylene glycol phantom and cell-containing bio-phantom, three different types of ASM images were created using different calculation processes. ASM/A is an image calculated by dividing the absolute difference between ADCb and ADCm by ADCb several times. By contrast, ASM/S is an image created by dividing the absolute difference between ADCb and ADCm by the standard deviation of ADCb several times. As for positive ASM/A image (PASM/A), the positive image, which was resultant after subtracting ADCb from ADCm, was divided by ADCb several times. A comparison was made between the types of ASM and DK images. The results showed the same tendency between ASM/A in addition to both ASM/S and PASM/A. By increasing the number of divisions by ADCb from three to five times, ASM/A images transformed from DK-mimicking to more RD-sensitive images compared with DK images. These observations suggest that ASM/A images may prove useful for future clinical applications in RD imaging protocols for the diagnosis of diseases.

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“…In terms of phantoms for RD, the PEG phantom has been reported to mimic the conditions of RD in vitro , indicating that it can be utilized as the standard phantom for RD imaging [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…The PEG phantom [ 16 ], which was used as the newly developed RD phantom [ 13 ], consisted of the following three components: i) PEG (cat. no.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Creation Of Dk Imagesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of calculation processes of apparent diffusion coefficient subtraction method (ASM) imaging

Barham

Kuroda²,

Yoshimura³

et al. 2023

PLoS ONE

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Understanding ADC variation by fat content effect using a dual-function MRI phantom

Liu,

Tsai,

et al. 2024

Eur Radiol Exp

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Background A dual-function phantom designed to quantify the apparent diffusion coefficient (ADC) in different fat contents (FCs) and glass bead densities (GBDs) to simulate the human tissues has not been documented yet. We propose a dual-function phantom to quantify the FC and to measure the ADC at different FCs and different GBDs. Methods A fat-containing diffusion phantom comprised by 30 glass-bead-containing fat-water emulsions consisting of six different FCs (0, 10, 20, 30, 40, and 50%) multiplied by five different GBDs (0, 0.1, 0.25, 0.5, and 1.0 g/50 mL). The FC and ADC were measured by the “iterative decomposition of water and fat with echo asymmetry and least squares estimation-IQ,” IDEAL-IQ, and single-shot echo-planar diffusion-weighted imaging, SS-EP-DWI, sequences, respectively. Linear regression analysis was used to evaluate the relationship among the fat fraction (FF) measured by IDEAL-IQ, GBD, and ADC. Results The ADC was significantly, negatively, and linearly associated with the FF (the linear slope ranged from -0.005 to -0.017, R2 = 0.925 to 0.986, all p < 0.001). The slope of the linear relationship between the ADC and the FF, however, varied among different GBDs (the higher the GBD, the lower the slope). ADCs among emulsions across different GBDs and FFs were overlapped. Emulsions with low GBDs plus high FFs shared a same lower ADC range with those with median or high GBDs plus median or lower FFs. Conclusions A novel dual-function phantom simulating the human tissues allowed to quantify the influence of FC and GBD on ADC. Relevance statement The study developed an innovative dual-function MRI phantom to explore the impact of FC on ADC variation that can affect clinical results. The results revealed the superimposed effect on FF and GBD density on ADC measurements. Key points • A dual-function phantom made of glass bead density (GBD) and fat fraction (FF) emulsion has been developed. • Apparent diffusion coefficient (ADC) values are determined by GBD and FF. • The dual-function phantom showed the mutual ADC addition between FF and GBD. Graphical Abstract

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Development of a standard phantom for diffusion-weighted magnetic resonance imaging quality control studies: A review

Manson

Mumuni

Shirazu

et al. 2022

Polish Journal of Medical Physics and Engineering

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Various materials and compounds have been used in the design of diffusion-weighted magnetic resonance imaging (DWMRI) phantoms to mimic biological tissue properties, including diffusion. This review thus provides an overview of the preparations of the various DW-MRI phantoms available in relation to the limitations and strengths of materials/solutions used to fill them. The narrative review conducted from relevant databases shows that synthesizing all relevant compounds from individual liquids, gels, and solutions based on their identified strengths could contribute to the development of a novel multifunctional DW-MRI phantom. The proposed multifunctional material at varied concentrations, when filled into a multi-compartment Perspex container of cylindrical or spherical geometry, could serve as a standard DW-MRI phantom. The standard multifunctional phantom could potentially provide DW-MRI quality control test parameters in one study session.

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Development of a novel phantom using polyethylene glycol for the visualization of restricted diffusion in diffusion kurtosis imaging and apparent diffusion coefficient subtraction method

Cited by 4 publications

References 26 publications

Evaluation of calculation processes of apparent diffusion coefficient subtraction method (ASM) imaging

Evaluation of calculation processes of apparent diffusion coefficient subtraction method (ASM) imaging

Understanding ADC variation by fat content effect using a dual-function MRI phantom

Development of a standard phantom for diffusion-weighted magnetic resonance imaging quality control studies: A review

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