Development of a novel pH sensitive silane crosslinked injectable hydrogel for controlled release of neomycin sulfate

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

“…Neomycin sulphate is one of the most frequently used topical antibiotics for the treatment of diabetic ulcers, which has been incorporated in other polymeric matrixes, eg, gelatin and PVA blends . It is water soluble and stable in aqueous solutions.…”

“…It retards the growth of both Gram‐positive and Gram‐negative bacteria, and it has low absorption by the organism, leading to an accumulation of the drug in the wound site when applied topically. However, its prolonged use may cause allergy reactions . An alternative to synthetic antibiotics is the use of natural compounds against infections.…”

“…28 Neomycin sulphate is one of the most frequently used topical antibiotics for the treatment of diabetic ulcers, which has been incorporated in other polymeric matrixes, eg, gelatin 29 and PVA blends. 30 It is water soluble and stable in aqueous solutions. It retards the growth of both Gram-positive and Gram-negative bacteria, and it has low absorption by the organism, leading to an accumulation of the drug in the wound site when applied topically.…”

“…However, its prolonged use may cause allergy reactions. [30][31][32] An alternative to synthetic antibiotics is the use of natural compounds against infections. Plants and other natural products have been studied to identify their bactericide, fungicide, antiviral, anti-inflammatory, and antioxidant action and to overcome the problems caused by classic antibiotics.…”

Reversible swelling behaviour of Diels–Alder clicked chitosan hydrogels in response to pH changes

“…According to this, the most attractive route of controlled release is by pH triggering, knowing that the pH gradient in the human gastrointestinal (GI) tract ranges from 1 to 7.5 [2] and, moreover, decreased pH values are found close to tumors or infarcted areas [3][4][5][6]. Several attempts, mainly focused on covalently cross-linked hydrogels, have been made in recent years to design materials with enhanced stimuli-sensitive performance to be used as drug carrier vehicles [7][8][9][10]. In this sense, our most recent investigations indicated that chitosan could be successfully crosslinked using Diels-Alder 'click' cycloaddition for hydrogel formation [11][12][13].…”