Development of a Novel Method for the Preparation of Thiolated Polyacrylic Acid Nanoparticles

Greindl, Melanie; Bernkop‐Schnürch, Andreas

doi:10.1007/s11095-006-9087-1

Cited by 31 publications

(14 citation statements)

References 29 publications

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“…Due to these bonds, particles stable under acidic conditions and with longer residence time in the gastrointestinal tract were obtained, seeming to be suitable to deliver therapeutic proteins, genes, or antigens orally as well as transdermally. [149] Zelikin et al demonstrated that the stability of layer-by-layer (LbL) films can be controlled via disulfides. Polymethacrylic acid was functionalized with cysteamine, and this polymer was applied for the fabrication of capsules with polyvinylpyrrolidone (PVP).…”

Section: Disulfides For the Stabilization Of The Carriermentioning

confidence: 99%

Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems

et al. 2009

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Nucleic acids are not only expected to assume a pivotal position as "drugs" in the treatment of genetic and acquired diseases, but could also act as molecular cues to control the microenvironment during tissue regeneration. Despite this promise, the efficient delivery of nucleic acids to their side of action is still the major hurdle. One among many prerequisites for a successful carrier system for nucleic acids is high stability in the extracellular environment, accompanied by an efficient release of the cargo in the intracellular compartment. A promising strategy to create such an interactive delivery system is to exploit the redox gradient between the extra- and intracellular compartments. In this review, emphasis is placed on the biological rationale for the synthesis of redox sensitive, disulfide-based carrier systems, as well as the extra- and intracellular processing of macromolecules containing disulfide bonds. Moreover, the basic synthetic approaches for introducing disulfide bonds into carrier molecules, together with examples that demonstrate the benefit of disulfides at the individual stages of nucleic acid delivery, will be presented.

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Section: Disulfides For the Stabilization Of The Carriermentioning

confidence: 99%

Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems

et al. 2009

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“…Secondly, the use of polymeric materials for NP preparation allows controlled drug release in combination with a complete drug protection (Nahar et al 2006). Thiolated chitosan and thiolated poly (acrylic acid) have been utilized in formulating nanoparticles for sustained drug delivery (Greindl and Bernkop-Schnürch 2006;Deutel et al 2008). NP consisting of thiomers are covalently cross-linked via disulphide bonds.…”

Section: Preparation Of Nanoparticles Via High Pressure Homogenizermentioning

confidence: 99%

Preparation and evaluation of thiomer nanoparticles via high pressure homogenization

Hoyer¹,

Schlocker²,

Greindl³

et al. 2010

Journal of Microencapsulation

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The aim of this study was to establish and evaluate a high pressure homogenization method for the preparation of thiomer nanoparticles. Particles were formulated by incorporation of the model protein horseradish peroxidase in chitosan-glutathione (Ch-GSH) and poly(acrylic acid)-glutathione (PAA-GSH) via co-precipitation followed by air jet milling. The resulting microparticles were suspended in distilled water using an Ultraturax and subsequently micronized by high pressure homogenization. Finally, resulting particles were evaluated regarding size distribution, shape, zeta potential, drug load, protein activity and release behaviour. The mean particle size after 30 cycles with a pressure of 1500 bar was 538 +/- 94 nm for particles consisting of Ch-GSH and 638 +/- 94 nm for particles consisting of PAA-GSH. Nanoparticles of Ch-GSH had a positive zeta-potential of +1.03 mv, whereas nanoparticles from PAA-GSH had a negative zeta potential of -6.21 mv. The maximum protein load for nanoparticles based on Ch-GSH and based on PAA-GSH was 45 +/- 2% and 37 +/- %, respectively. The release profile of nanoparticles followed a first order release kinetic. Thiolated nanoparticles prepared by a high pressure homogenization technique were shown to be stable and provide controlled drug release characteristics. The preparation method described here might be a useful tool for a more upscaled production of nanoparticulate drug delivery systems.

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“…Otherwise, the polymer absorbs sunlight and would be photo-oxidized easily (Kriwet et al 1998;Marschütz and Bernkop-Schnürch 2002;Zhong and Ha 2011;De et al 2003). Because of their structure stability, inoxidizability, media resistance, and transparency, acrylic polymers are weather resistant (Chen et al 2005;Fan and Zhang 2011;Yi et al 2008;Greindl and Bernkop-Schnürch 2006;Chen et al 2008;Kanou 1996) and can be used as a crude material for preparing a water-resistant material.…”

Section: Introductionmentioning

confidence: 99%

Water-Resistant Material from Recovered Fibers and Acrylic Emulsion Terpolymer

Chen¹,

Wu²

2014

BioResources

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Styrene (SM), methyl methacrylate (MMA), and butyl acrylate (BA) were used to synthesize a polyacrylic emulsion by core-shell emulsion polymerization. The solid content of the emulsion reached 40% using reasonable reactive emulsifier contents and feeding modes. Then, the emulsion and a fiber were dispersed, coated, and dried together. Finally, fiber-based water-resistant material was successfully fabricated. The experimental results showed that under the conditions of a monomer mass ratio of 1:1:1 and a mass ratio of polyacrylic emulsion to fiber of 2:1, the Cobb value of the material reached 5.0 g/m 2 . The tensile strength, elongation, and breaking length were 7.4225 kN/m, 1.0%, and 11.706 km, respectively. Using scanning electron microscopy (SEM) to analyze the surface morphology and internal structure of products, the reasons for the high water resistance of fiber-based material was due to the bonding and filling effects of the polyacrylic emulsion on the fibers. For tightly bound fibers, the porous structures formed in fiber-based boards were reduced. On the other hand, the polyacrylic emulsion filled the gaps between fibers. This filling effect led to a continuous structure, and the water resistance of the material was further enhanced.

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Development of a Novel Method for the Preparation of Thiolated Polyacrylic Acid Nanoparticles

Abstract: This novel nanoparticulate delivery system seems to be a promising vehicle for the administration of therapeutic proteins, genes and antigens via mucosal membranes.

Cited by 31 publications

References 29 publications

Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems

Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems

Preparation and evaluation of thiomer nanoparticles via high pressure homogenization

Water-Resistant Material from Recovered Fibers and Acrylic Emulsion Terpolymer

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