Development of a novel loading device for studying magnesium degradation under compressive load for implant applications

Tian, Qiang; Mendeza, Jose Antonio; Rovedatti, L.; Mahmood, Omar; Showalter, Adam; Ang, Elizabeth; Kazmi, Sarah; Liu, Huinan

doi:10.1016/j.matlet.2017.12.147

Cited by 14 publications

(5 citation statements)

References 14 publications

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“…It has been reported that both abundant body fluids (e.g. blood) and mechanical stress could further accelerate degradation of Mg-based implants 11,12 . Moreover, rapid degradation of Mg-based implants may lead to local pH increase, hydrogen gas accumulation, and early mechanical failure that are undesirable in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Nano-to-Submicron Hydroxyapatite Coatings for Magnesium-based Bioresorbable Implants – Deposition, Characterization, Degradation, Mechanical Properties, and Cytocompatibility

Tian

Lin

Rovedatti

et al. 2019

Sci Rep

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Magnesium (Mg) and its alloys have shown attractive biocompatibility and mechanical strength for medical applications, but low corrosion resistance of Mg in physiological environment limits its broad clinical translation. Hydroxyapatite (HA) nanoparticles (nHA) are promising coating materials for decreasing degradation rates and prolonging mechanical strength of Mg-based implants while enhancing bone healing due to their osteoconductivity and osteoinductivity. Conformal HA coatings with nano-to-submicron structures, namely nHA and mHA coatings, were deposited successfully on Mg plates and rods using a transonic particle acceleration (TPA) process under two different conditions, characterized, and investigated for their effects on Mg degradation in vitro. The nHA and mHA coatings enhanced corrosion resistance of Mg and retained 86–90% of ultimate compressive strength after in vitro immersion in rSBF for 6 weeks, much greater than non-coated Mg that only retained 66% of strength. Mg-based rods with or without coatings showed slower degradation than the respective Mg-based plates in rSBF after 6 weeks, likely because of the greater surface-to-volume ratio of Mg plates than Mg rods. This indicates that Mg-based plate and screw devices may undergo different degradation even when they have the same coatings and are implanted at the same or similar anatomical locations. Therefore, in addition to locations of implantation, the geometry, dimension, surface area, volume, and mass of Mg-based implants and devices should be carefully considered in their design and processing to ensure that they not only provide adequate structural and mechanical stability for bone fixation, but also support the functions of bone cells, as clinically required for craniomaxillofacial (CMF) and orthopedic implants. When the nHA and mHA coated Mg and non-coated Mg plates were cultured with bone marrow derived mesenchymal stem cells (BMSCs) using the in vitro direct culture method, greater cell adhesion densities were observed under indirect contact conditions than that under direct contact conditions for the nHA and mHA coated Mg. In comparison with non-coated Mg, the nHA and mHA coated Mg reduced BMSC adhesion densities directly on the surface, but increased the average BMSC adhesion densities under indirect contact. Further long-term studies in vitro and in vivo are necessary to elucidate the effects of nHA and mHA coatings on cell functions and tissue healing.

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Section: Introductionmentioning

confidence: 99%

Nano-to-Submicron Hydroxyapatite Coatings for Magnesium-based Bioresorbable Implants – Deposition, Characterization, Degradation, Mechanical Properties, and Cytocompatibility

Tian

Lin

Rovedatti

et al. 2019

Sci Rep

Self Cite

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“…However, Mg-based materials corrode more rapidly under compressive loading, and this investigation is important in bridging the gap between in vivo and in vitro yields. Also to reduce the number of animals required for research in this area [20].…”

Section: Mg-based Composite For Implant Applicationmentioning

confidence: 99%

The Manufacturing Process and Corrosion Properties of Magnesium Matrix Composites: A Review

Zuliantoni,

Smaradhana

2024

memi

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Magnesium-based biomaterials are a new generation of biodegradable metals that are playing a major role in the development of future implant materials. Magnesium-based materials can corrode too rapidly during physiological conditions and lose their usefulness before bones heal. This review aims to provide a comprehensive overview of the selection of suitable matrix and reinforcing materials as well as suitable process techniques to achieve better corrosion resistance targeted for dental implant applications. It also discusses the advantages and disadvantages of testing methods and corrosion media commonly used for biomedical applications. Specific search strategies are carried out in electronic databases: Springer, Pubmed, and Sciencedirect as well as google without limiting years. Papers are selected after reviewing their title, abstract, and full text. Then study the objectives, criteria, methods, and results. Based on the available literature, we can conclude that for magnesium-based composite matrices it is preferable to use commercially available Mg AZ91D alloys to investigate their corrosion behavior in vitro and in vivo environments. While for the composite reinforcement, bioceramic materials can be used, including Hydroxyapatite (HA) added with Zirconia ceramics (ZrO2) or Titanium metal oxide (TiO2). Furthermore, the process of making ceramic composites uses powder metallurgy (PM) and squeeze casting methods. Then, corrosive testing can use the commonly used electrochemical methods, namely Potentiodynamic Polarization (PDP) and Electrochemical Impedance Spectroscopy (EIS) with corrosive SBF media.

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“…Magnesium has attracted much attention in the research and application of orthopedic degradable implants because of its mechanical properties and its degradability [1,2]. Since the magnesium implants may be subjected to various loads, plenty of studies were conducted to the magnesium degradation under loads, including in vitro studies and in vivo studies.…”

Section: Introductionmentioning

confidence: 99%

A Novel Device for Studying in Vivo Magnesium Degradation under Controllable Cyclic Load in the Rabbit Model

Zhang

Hao

2023

J. Phys.: Conf. Ser.

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Magnesium is an important material for medical implants due to its special properties including biocompatibility, low density, high mechanical property, and biodegradability. The in vivo implantation experiment of magnesium is an important experimental method to obtain its degradation characteristics. In recent years, although in vitro studies have found that the degradation of magnesium under cyclic loading is different from static loading, there is the lack of in vivo experiment to verify the above in vitro results, while the degradation characteristic of magnesium under load is an important factor to be considered when magnesium is used as orthopedic implant. We designed a novel device to apply controllable cyclic load onto the magnesium material implanted in the rabbit tibia, containing loading chamber, motor and gear reduction mechanism, and Singlechip Computer, etc. The conducted experiments have shown that the devices were able to apply load onto the implanted magnesium in rabbits in vivo during unrestricted cage activity for at least 16 days. Likewise, no distortion or infections were observed. Results demonstrated that the novel device was able to produce alteration of the mechanical environment in vivo rabbit tibia, which showed that the load device is suitable for in vivo loading degradation characteristics testing of magnesium or magnesium alloys.

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Development of a novel loading device for studying magnesium degradation under compressive load for implant applications

Cited by 14 publications

References 14 publications

Nano-to-Submicron Hydroxyapatite Coatings for Magnesium-based Bioresorbable Implants – Deposition, Characterization, Degradation, Mechanical Properties, and Cytocompatibility

Nano-to-Submicron Hydroxyapatite Coatings for Magnesium-based Bioresorbable Implants – Deposition, Characterization, Degradation, Mechanical Properties, and Cytocompatibility

The Manufacturing Process and Corrosion Properties of Magnesium Matrix Composites: A Review

A Novel Device for Studying in Vivo Magnesium Degradation under Controllable Cyclic Load in the Rabbit Model

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