Development of a novel ionic support and its application in the ionic liquid phase assisted synthesis of a potent antithrombotic

Ionic-Liquid-Supported Synthesis: A Novel Liquid-Phase Strategy for Organic Synthesis

“…44 The ionic liquid support 74, bearing a formyl functional group, was prepared from 4-hydroxy-2-methoxybenzaldehyde, 1, 4-dichlorobutane, and 1-methylimidazole (Scheme 19). Reductive amination of the IL-supported 74 with the protected tyrosine 75 gave the IL-supported substrate 76.…”

Task‐Specific Ionic Liquids

“…This approach was used by de Kort et al for the multistep synthesis of an antithrombotic drug. [20] After cleavage from the IL, the product was obtained in 11 % overall yield following a seven-step one-pot synthesis. An application in combinatorial chemistry was reported by Fraga-Dubreuil and Bazureau.…”

Combinatorial Chemistry Online

“…Small ligands that are able to specifically interact with proteins can be effective tools in the search for proteome function. Combinatorial Chemistry -An Online Journal 6 (2004) [13][14][15][16] these approaches generally use only one protein target, and given the high number of proteins in mammalian organisms, high-throughput screening procedures have been developed to handle this task. A potential drawback with such methods is that the full range of proteins the chosen ligand may interact with are not discovered if the screening is performed with only one or a few proteins.…”

“…15 The potential was further exemplified by the use in a one-pot multistep ionic liquid phase assisted synthesis of a tirofiban analogue.…”