Development of a novel herbicide, metazosulfuron

Saeki, Manabu; Yano, Tetsuhiko; Nakaya, Yoshihiko; Tamada, Yoshitake

doi:10.1584/jpestics.j16-04

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Recently developed sulfonylurea ALS inhibitors include propyrisulfuron (Zeta-One ® ) from Sumitomo Chemical 91) and metazosulfuron (Altair ® ) from Nissan Chemical. 92) Both herbicides have been developed for paddy rice and are characterized by their effectiveness against broadleaf weeds and Cyperaceous weeds, as well as against barnyard grass, which is difficult to control with conventional sulfonylurea herbicides.…”

Section: Herbicides Developed After 2008mentioning

confidence: 99%

Development of novel pesticides in the 21st century

2020

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General trends and strategies for novel pesticides are summarized. Global pesticide sales and pesticide discovery research are also briefly reviewed. At least 105 chemical pesticides have been launched during the past decade or are under development: 43 fungicides, 34 insecticides/acaricides, 6 nematicides, 21 herbicides, and 1 herbicide safener. Most of them are safe to humans and environmentally friendly. The most developed fungicides are SDHI (succinate dehydrogenase inhibitors), DMI (demethylation inhibitors), QoI (quinone outside inhibitors), and QiI (quinone inside inhibitors). Due to the development of resistance to fungicides with existing modes of action, many fungicides possessing various novel modes of action have been launched or are under development. The trend of insecticide development is changing from organophosphorus, carbamate, and synthetic pyrethroids to nicotinic and diamide insecticides. During the past decade, compounds possessing a variety of novel modes of action have also been launched or are under development. Flupyradifurone and flupyrimin, exhibiting extremely low honeybee toxicity, have been developed and subjected to practical use. Herbicides possessing varied modes of action, such as acetolactate synthase, p-hydroxyphenylpyruvate dioxygenase, protoporphyrinogen oxidase, and very-long-chain fatty acid elongase inhibition, have been developed, but no herbicides possessing a novel mode action have commercialized in nearly 30 years. It is of interest that cyclopyrimorate, which was recently launched, and tetflupyrolimet, which is under development, have novel modes action: homogentisate solanesyltransferase (HST) and dihydroorotate dehydrogenase (DHODH) inhibition, respectively. The development of useful acaricides and nematicides is also progressing. Some natural product origin pesticides are getting attention.

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Section: Herbicides Developed After 2008mentioning

confidence: 99%

Development of novel pesticides in the 21st century

2020

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“…The exchange of one of the two different amide functions of the lead compound 1 by an isoxazoline led to a further 20-fold potency increase and the discovery of the oxysterol-binding protein inhibitor oxathiapiprolin ( 2 ), which is currently the most active commercialized fungicide against oomycetes diseases, such as potato late blight, caused by Phytophthora infestans, and grape downy mildew, caused by Plasmopara viticola. , The cyclization of N -methoxycarbamate toxophore of the complex III Qo site inhibitor pyraclostrobin ( 3 ) to N -methyltetrazolone delivered metyltetraprole ( 4 ). This new fungicide possesses high potency against Septoria tritici, a causal agent of wheat leaf blotch, in contrast to its lead compound pyraclostrobin also against the Qo-resistant Septoria mutation G143A. , The replacement of the methylester of the acetolactate synthase (ALS)-inhibiting herbicide halosulfuron ( 5 ) by dioxazine delivered metazosulfuron ( 6 ), an herbicide developed for the control of annual and perennial weeds in paddy field rice. , One of dithiopyr’s ( 7 ) two thioester functions is well-mimicked by a thiazoline ring, as demonstrated by the closely related microtubulin assembly inhibiting herbicide thiazopyr ( 8 ). , Also, the alanine moiety of the RNA polymerase inhibiting fungicide metalaxyl ( 9 ) can be exchanged by oxazolone, leading to oxadixyl ( 10 ) (Scheme ). , …”

Section: Ring Closure By Replacement Of Carboxylic Functions With Cyc...mentioning

confidence: 99%

Ring Closure and Ring Opening as Useful Scaffold Hopping Tools in Agrochemistry

Lamberth

2023

J. Agric. Food Chem.

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Ring closing acyclic parts of a molecular scaffold or the opposite manipulation, opening rings to produce pseudo-ring structures, is an important scaffold hopping manipulation. Analogues derived from biologically active compounds through the utilization of such strategies are often similar in shape and physicochemical properties and, therefore, likely to exhibit similar potency. This review will demonstrate how several different ring closure techniques, such as replacing carboxylic functions by cyclic peptide mimics, incorporating double bonds into aromatic rings, tying back ring substituents to a bicyclic structure, cyclizing adjacent ring substituents to an annulated ring, bridging annulated ring systems to tricyclic scaffolds, and exchanging gem-dimethyl groups by cycloalkyl rings, but also ring opening led to the discovery of highly active agrochemicals.

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“…Против однолетних двудольных сорняков хорошо зарекомендовали себя гербициды на основе метрибузина и прометрина, а по отношению к многолетним -глифосатсодержащие гербициды осенью [3,4]. В то же время в научном мире продолжается поиск и изучение соединений с гербицидной активностью в новых классах химических веществ как для общего контроля [5,6], так и отдельно однолетних [7] и двудольных [8] Гербициды почвенного действия (Гамбит, СК и Лазурит, СП) создают почвенный «экран», защищающий культуру от последующих «волн» нежелательной растительности до двух месяцев. Наблюдения, проведенные в течение 15 суток после обработки этими гербицидами, показали, что в вариантах опыта появились единичные растения многолетних растений, а также всходы подмаренника цепкого и амаранта запрокинутого.…”

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Effectiveness of herbicides of JSC August company on potatoes

Зейрук¹,

Васильева²,

Belov³

et al. 2021

Kartofel` I Ovoshi

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Проведена полевая оценка биологической и хозяйственной эффективности гербицида сплошного действия Торнадо 500, ВР и двух схем применения гербицидов из разных химических классов АО Фирма «Август» против наиболее распространенных видов сорной растительности. Исследования проводили в 2017–2019 годах на экспериментальной базе «Коренево» (Люберецкий район Московской области) на участке, предназначенном под посадку картофеля, и непосредственно на посадках сорта Колобок. Густота посадки – 44 тыс. клубней/га (75×30 см). Срок посадки – первая декада мая. Все учеты, определение эффективности, статистическую обработку проводили по общепринятым методикам. Учеты засоренности выполняли подсчетом сорняков на пробных площадках по 0,25 м2 в шахматном порядке в десяти местах. Учеты проводили через месяц, полтора месяца и перед уборкой урожая картофеля. Первая схема состояла из довсходовой обработки Гамбитом, СК, 3,5 л/га и послевсходовой – баковой смесью препаратов Эскудо, ВДГ, 0,025 кг/га, и Лазурит Супер, КНЭ, 0,4 л/га. Вторая схема: дробное внесение Лазурита, СП – в довсходовый период, 0,8 кг/га, и при достижении растениями картофеля высоты 5–10 см – 0,3 кг/га с добавлением Эскудо, ВДГ, 0,025 кг/га. Обе схемы применяли с добавлением адъюванта Аллюр, Ж, 0,2 л/га. При изучении видового состава сорняков выявлено, что наибольшую долю в общем их количестве занимают из малолетних: марь белая, аистник, трехреберник непахучий и из многолетних – осот полевой и пырей ползучий. Биологическая эффективность осенней обработки гербицидом Торнадо 500, ВР составила 92,1–97,3%. Биологическая эффективность первой схемы в среднем за два года достигала 75,6–98,3%, второй – 68,9–93,4%. Применение гербицидов АО Фирма «Август» на среднеспелом сорте Колобок в условиях различного обеспечения влагой вегетационных периодов 2017–2019 годов обеспечило прибавку валовой урожайности на 25,8 и 24,2% соответственно по сравнению с контролем (24,8 т/га). A field assessment of the biological and economic effectiveness of the continuous-action herbicide Tornado 500, BP and two schemes for the use of herbicides from different chemical classes of JSC August company against the most common types of weed vegetation was carried out. The research was carried out in 2017–2019 at the experimental base Korenevo (Lyuberetsky district of the Moscow region) on a plot intended for planting potatoes and directly on the plantings of the Kolobok variety. Planting density – 44 thousand tubers/ha (75×30 cm). The planting period is the first decade of May. All accounting, efficiency determination, and statistical processing were carried out according to generally accepted methods. The infestation counts were carried out by counting weeds on test sites of 0.25 m2 in a staggered order in ten places. The surveys were carried out after a month, a month and a half, and before the potato harvest. The first scheme consisted of pre-emergence treatment with Gambit, SC, 3,5 l/ha and post-emergence-tank mixture of Escudo, EDG, 0,025 kg/ha and Lazurit Super, KNE, 0,4 l/ha. The second scheme: fractional application of Lazurit, SP – in the pre-emergence period of 0,8 kg/ha and when the potato plants reach a height of 5–10 cm 0,3 kg/ha with the addition of Escudo, EDG, 0,025 kg/ha. Both schemes were used with the addition of the adjuvant Allure, W, 0,2 l/ha. When studying the species composition of weeds, it was revealed that the largest share in their total number is occupied by young ones: white marsh, erodium, scentless false mayweed and from perennial ones-field sedge and creeping wheatgrass. The biological efficiency of the autumn treatment with the herbicide Tornado 500, BP was 92,1–97,3%. The biological efficiency in the average two years of the first scheme was 75,6–98,3%, the second – 68,9–93,4%. The use of herbicides of JSC August company on the medium-ripe variety Kolobok in conditions of various moisture supply of the growing seasons of 2017–2019 provided an increase in the gross yield of 25,8 and 24,2%, respectively, compared to the control (24,8 t/ha).

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Development of a novel herbicide, metazosulfuron

Cited by 5 publications

References 2 publications

Development of novel pesticides in the 21st century

Development of novel pesticides in the 21st century

Ring Closure and Ring Opening as Useful Scaffold Hopping Tools in Agrochemistry

Effectiveness of herbicides of JSC August company on potatoes

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