Development of a novel dosing paradigm to model diazepam rescue therapy in preclinical seizure and epilepsy models
Michelle Guignet,
H. Steve White,
Sunita N. Misra
et al.
Abstract:Diazepam is a cornerstone immediate‐use antiseizure rescue therapy that may extend the duration between seizure clusters in people living with epilepsy. However, our mechanistic understanding of intermittent rescue therapy on disease progression is limited by the lack of suitable preclinical models. Specifically, the pharmacokinetics of diazepam varies widely between humans and laboratory animals. Here, we developed a novel repeat rescue therapy dosing paradigm in rats to maintain prolonged therapeutic concent… Show more
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