Development of a Novel CaP-Containing Mesoporous Silica-Based Xerogels Used as Hemostatic Material with Good Biodegradability and Low Heat Generation

Abstract

A novel Ca/P-containing mesoporous silica-based xerogels (CaMSX) with good degradability and low heat generation were synthesized for hemorrhage control by a modified sol-gel process and physicochemically characterized. The mesoporous silica-based xerogels without Ca/P (MSX) was also prepared as comparison. The in vitro whole blood coagulation time, activated partial thromboplastin time (APTT) and prothrombin time (PT) of the CaMSX were measured with MSX, Chinese traditional medicin-Yunnan medical powder (YM) and traditional zeolite. In vivo bleeding model was tested with rabbit’ ear side veins. The results illustrated that the CaMSX could remarkably promote the intrinsic and extrinsic blood coagulation processes which greatly depend on the dosage and the content of Ca in the CaMSX. The CaMSX had better efficiency in promoting coagulation process than that of MSX, YM and zeolite.

Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery

“…Novel Ca/P-containing mesoporous silica-based xerogels (also known as CaMXS) with good biodegradability and low heat generation have been developed for hemorrhage control. 15 This type of hemostatic nanomaterial possesses uniform tunable nanopores (sizes less than 50 nm) and high specific surface areas (up to 1,400 m 2 /g) and high biodegradability. 16 CaMXS exhibited good coagulation function evaluated by whole blood and accelerated both the intrinsic and extrinsic coagulation processes.…”

“…On the one hand, the great surface area and water adsorption capability of the silica-based xerogel can rapidly counterbalance the hydration heat energy to overcome the disadvantages of exothermic zeolite materials when contacting with blood. 15,17,18 On the other hand, tailored mesoporous structure and pore sizes are attributed to the superfast hemostatic effects of nanomesoporous molecular sieves. Silicabased xerogel is also a biologically active and biodegradable material; it can release Si ions during degradation and the proper concentration of released Si ions is known to stimulate bone cell functions and accelerate bone healing.…”

“…50,51 Hemostatic mechanisms of nanomaterials Table 1 provides an "at-a-glance" summary of various representative hemostatic materials along with characteristic evaluations. 53 Figure 1 shows the morphology of several hemostatic materials, 15,35,54 many of which have been reviewed in the previous section. In this section, understandings of important hemostatic mechanisms of nanomaterials are discussed, beginning with a brief review of the physiology of hemostatic procedure.…”