Development of a nomogram using fundus photography to predict glaucoma progression in patients showing disc hemorrhage

Kim, Sangah; Park, Chan Keum; Kim, Eun Woo; Lee, Sang Yeop; Seong, Gong Je; Kim, Chan Yun; Bae, Hyoung Won

doi:10.1038/s41598-020-71183-8

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Nomograms have been used in a variety of ocular diseases, such as for predicting glaucoma progression in patients showing disc haemorrhage based on risk factors [ 23 ] and in the prognosis of metastatic uveal melanoma according to the patient’s systemic condition, such as the percentage of liver involvement and lactate dehydrogenase (LDH) level [ 24 ]. Therefore, the concept of predicting a diagnosis of oGVHD according to the patient’s systemic condition through a nomogram is very promising.…”

Section: Discussionmentioning

confidence: 99%

A nomogram model for predicting ocular GVHD following allo-HSCT based on risk factors

et al. 2023

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Objective To develop and validate a nomogram model for predicting chronic ocular graft-versus-host disease (coGVHD) in patients after allogenic haematopoietic stem cell transplantation (allo-HSCT). Methods This study included 61 patients who survived at least 100 days after allo-HSCT. Risk factors for coGVHD were screened using LASSO regression, then the variables selected were subjected to logistic regression. Nomogram was established to further confirm the risk factors for coGVHD. Receiver operating characteristic (ROC) curves were constructed to assess the performance of the predictive model with the training and test sets. Odds ratios and 95% confidence intervals (95% CIs) were calculated by using logistic regression analysis. Results Among the 61 patients, 38 were diagnosed with coGVHD. We selected five texture features: lymphocytes (LYM) (OR = 2.26), plasma thromboplastin antecedent (PTA) (OR = 1.19), CD3 + CD25 + cells (OR = 1.38), CD3 + HLA-DR + cells (OR = 0.95), and the ocular surface disease index (OSDI) (OR = 1.44). The areas under the ROC curve (AUCs) of the nomogram with the training and test sets were 0.979 (95% CI, 0.895–1.000) and 0.969 (95% CI, 0.846–1.000), respectively.And the Hosmer–Lemeshow test was nonsignificant with the training (p = 0.9949) and test sets (p = 0.9691). Conclusion We constructed a nomogram that can assess the risk of coGVHD in patients after allo-HSCT and help minimize the irreversible loss of vision caused by the disease in high-risk populations.

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Section: Discussionmentioning

confidence: 99%

A nomogram model for predicting ocular GVHD following allo-HSCT based on risk factors

et al. 2023

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An effective model of clinical examination and monitoring of glaucoma patients

Дорофеев¹,

Baryshnikova

Kirilik³

et al. 2022

Glaucoma

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Open-angle glaucoma is a chronic progressive optic neuropathy characterized by morphological changes in the optic nerve head and retinal nerve fibers layer in the absence of other eye diseases.Regular medical check-ups are necessary to assess the progression of glaucoma, to correct the treatment regimen or prescribe surgical interventions, to control the stabilization of the glaucoma process and to preserve visual functions for longer period. When planning the number of monitoring visits, it is necessary to carefully study the prognostic risk factors, since they are statistically associated with the development and progression of glaucoma. Closer observation of patients with glaucoma reduces the risk of irreversible changes in the organ of vision.Patient compliance is of particular importance in the progression of glaucoma. The adherence rate in the treatment of glaucoma is relatively lower compared to other chronic diseases that require lifelong treatment.Currently, there is no effective model of regular checkups for glaucoma patients, therefore this direction requires improvement and development, both in the standards and timing of patient examination, and in the use of remote methods of glaucoma control. The disadvantage of the current medical check-ups routine is the lack of individual approach to patients, lack of equipment in the offices of regional ophthalmologists, and lack of specialized glaucoma offices.The tense epidemiological situation during the Covid-19 pandemic, gave understanding that while in-person consultations and remote consultations (telemedicine) cannot replace each other, a combination of these methods is cost-effective, can reduce the uneven distribution of ophthalmic resources, reduce the burden on the doctor and the rate of misdiagnosis. The situation was aggravated by the closure of ophthalmological hospitals and an increase in the waiting time for consultation in higher specialized medical institutions, which probably entails an increase in patients with progression of the glaucomatous process and the economic burden on both the state and the patients themselves.Telemedicine should be gradually introduced into everyday practice, for which it is advisable to create a single database of glaucoma patients to track the glaucomatous process.

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Development of a nomogram using fundus photography to predict glaucoma progression in patients showing disc hemorrhage

Abstract: reviewed and approved this study. Also, our approving IRB waived the need for us to obtain informed consent for study participations. All study conduct adhered to the tenets of the Declaration of Helsinki.

Cited by 2 publications

References 30 publications

A nomogram model for predicting ocular GVHD following allo-HSCT based on risk factors

A nomogram model for predicting ocular GVHD following allo-HSCT based on risk factors

An effective model of clinical examination and monitoring of glaucoma patients

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